Table 1. ADA enzyme activity and... | American Society of Hematology

Table 1.

ADA enzyme activity and percentage of cells containing LASN in patient infusions

Infusion	Protocol day	ADA, nM/min/10⁸cells	LASN⁺ cells, %	Total cells infused × 10⁸	LASN⁺ cells infused × 10⁷
Patient 1
1	0	2.7	—	14	—
2	31	3.6	—	100	—
3	77	7.9	—	120	—
4	126	—	—	6	—
5	153	5.3	17.8	172	306
6	202	11.8	—	180	—
7	262	10.5	18.2	120	220
8	314	12.4	21.2	180	380
9^*	511	8.2	53.3	129	690
10^*	601	20.8	46.8	64	300
11^*	707	12.4	27.4	200	548
Patient 2
1	0	3.9	1.51	13	1.96
2	27	2.1	1.53	150	23
3	81	4.2	2.55	153	39
4	127	3.5	1.59	54	8.6
5^*	186	3.9	2.75	36.4	10
6^*	242	4	3	24	7.25
7^*	274	4.6	3.1	32	9.9
8^*	300	2.5	2.46	80.3	19.8
9^*	343	4.9	—	74.5	—
10^*	398	3.3	2.02	120	24
11^*	448	2.8	0.87	200	17.4
12^*	511	4	0.96	161	15.5

Infusion	Protocol day	ADA, nM/min/10⁸cells	LASN⁺ cells, %	Total cells infused × 10⁸	LASN⁺ cells infused × 10⁷
Patient 1
1	0	2.7	—	14	—
2	31	3.6	—	100	—
3	77	7.9	—	120	—
4	126	—	—	6	—
5	153	5.3	17.8	172	306
6	202	11.8	—	180	—
7	262	10.5	18.2	120	220
8	314	12.4	21.2	180	380
9^*	511	8.2	53.3	129	690
10^*	601	20.8	46.8	64	300
11^*	707	12.4	27.4	200	548
Patient 2
1	0	3.9	1.51	13	1.96
2	27	2.1	1.53	150	23
3	81	4.2	2.55	153	39
4	127	3.5	1.59	54	8.6
5^*	186	3.9	2.75	36.4	10
6^*	242	4	3	24	7.25
7^*	274	4.6	3.1	32	9.9
8^*	300	2.5	2.46	80.3	19.8
9^*	343	4.9	—	74.5	—
10^*	398	3.3	2.02	120	24
11^*	448	2.8	0.87	200	17.4
12^*	511	4	0.96	161	15.5

— indicates not available for analysis.

CD8-depleted cultures.