Correlations between patient covariates and early death
Characteristic . | Early death* . | TL† . | P . |
|---|---|---|---|
| Sex, no. (%) | NS | ||
| Male | 6 (75) | 29 (60) | — |
| Female | 2 (25) | 19 (40) | — |
| Birth weight, kg | 2.73 | 3.03 | NS |
| EGA, wk | 36 | 37 | — |
| Age at diagnosis, d | 8 | 13 | NS |
| Symptoms at diagnosis‡, no. (%) | 8 (100) | 27 (56) | .020 |
| WBC count, × 109/L | 100.2 | 39.8 | < .001 |
| Hemoglobin level, g/L | 14.2 | 14.2 | NS |
| Platelet count, × 109/L | 279 000 | 193 000 | NS |
| Peripheral blasts, % | 36 | 30 | NS |
| Bone marrow blasts, % | 31 | 24 | NS |
| AST level, U/L | 424 | 157 | .001 |
| ALT level, U/L | 480 | 145 | .005 |
| Trisomy 21 only, no. (%) | 4 of 6 (67) | 31 of 42 (74) | NS |
| Clearance of blasts, no. (%) | 3 of 8 (38) | 42 of 47 (89) | < .001 |
| Days to clearance from diagnosis | 43 | 58 | — |
| Normalized CBC§, no. (%) | 0 of 8 (0) | 35 of 47 (74) | < .001 |
| Days to normal CBC from diagnosis | — | 84 | — |
Characteristic . | Early death* . | TL† . | P . |
|---|---|---|---|
| Sex, no. (%) | NS | ||
| Male | 6 (75) | 29 (60) | — |
| Female | 2 (25) | 19 (40) | — |
| Birth weight, kg | 2.73 | 3.03 | NS |
| EGA, wk | 36 | 37 | — |
| Age at diagnosis, d | 8 | 13 | NS |
| Symptoms at diagnosis‡, no. (%) | 8 (100) | 27 (56) | .020 |
| WBC count, × 109/L | 100.2 | 39.8 | < .001 |
| Hemoglobin level, g/L | 14.2 | 14.2 | NS |
| Platelet count, × 109/L | 279 000 | 193 000 | NS |
| Peripheral blasts, % | 36 | 30 | NS |
| Bone marrow blasts, % | 31 | 24 | NS |
| AST level, U/L | 424 | 157 | .001 |
| ALT level, U/L | 480 | 145 | .005 |
| Trisomy 21 only, no. (%) | 4 of 6 (67) | 31 of 42 (74) | NS |
| Clearance of blasts, no. (%) | 3 of 8 (38) | 42 of 47 (89) | < .001 |
| Days to clearance from diagnosis | 43 | 58 | — |
| Normalized CBC§, no. (%) | 0 of 8 (0) | 35 of 47 (74) | < .001 |
| Days to normal CBC from diagnosis | — | 84 | — |
All data represent mean values. For early death, n = 8; for TL, n = 48.
EGA indicates estimated gestational age; CBC, complete blood count; NS, not significant; —, not applicable.
Represents 8 patients who died at younger than 9 months of age.
Represents 48 total patients in study.
Symptoms at diagnosis include hepatosplenomegaly, visceral effusions, and infiltrative skin rash (excluding petechiae).
Normalized CBC indicates normalization of complete blood count (ie, normal hemoglobin, WBC count, platelet count, and differential for age).