Correlations between patient covariates and recurrence of leukemia
Characteristic . | Acute leukemia* . | TL† . | P . |
|---|---|---|---|
| Sex, no. (%) | NS | ||
| Male | 7 (78) | 29 (60) | — |
| Female | 2 (25) | 19 (40) | — |
| Birth weight, kg | 3.22 | 3.03 | NS |
| EGA, wk | 39 | 37 | — |
| Age at diagnosis, d | 20 | 13 | NS |
| Symptoms at diagnosis‡, no. (%) | 1 (11) | 27 (56) | .025 |
| WBC count, × 109/L | 22.8 | 39.8 | NS |
| Hemoglobin level, g/L | 14.9 | 14.2 | NS |
| Platelet count, × 109/L | 121 000 | 193 000 | NS |
| Peripheral blasts, % | 22 | 30 | NS |
| Bone marrow blasts, % | 15 | 24 | NS |
| AST level, U/L | 84 | 157 | NS |
| ALT level, U/L | 91 | 145 | NS |
| Trisomy 21 only, no. (%) | 5 of 9 (56) | 31 of 42 (74) | .037 |
| Clearance of blasts, no. (%) | 8 of 9 (89) | 42 of 47 (89) | NS |
| Days to clearance | 91 | 58 | — |
| Normalized CBC§, no. (%) | 5 of 9 (56) | 35 of 47 (74) | NS |
| Days to normal CBC | 114 | 84 | — |
Characteristic . | Acute leukemia* . | TL† . | P . |
|---|---|---|---|
| Sex, no. (%) | NS | ||
| Male | 7 (78) | 29 (60) | — |
| Female | 2 (25) | 19 (40) | — |
| Birth weight, kg | 3.22 | 3.03 | NS |
| EGA, wk | 39 | 37 | — |
| Age at diagnosis, d | 20 | 13 | NS |
| Symptoms at diagnosis‡, no. (%) | 1 (11) | 27 (56) | .025 |
| WBC count, × 109/L | 22.8 | 39.8 | NS |
| Hemoglobin level, g/L | 14.9 | 14.2 | NS |
| Platelet count, × 109/L | 121 000 | 193 000 | NS |
| Peripheral blasts, % | 22 | 30 | NS |
| Bone marrow blasts, % | 15 | 24 | NS |
| AST level, U/L | 84 | 157 | NS |
| ALT level, U/L | 91 | 145 | NS |
| Trisomy 21 only, no. (%) | 5 of 9 (56) | 31 of 42 (74) | .037 |
| Clearance of blasts, no. (%) | 8 of 9 (89) | 42 of 47 (89) | NS |
| Days to clearance | 91 | 58 | — |
| Normalized CBC§, no. (%) | 5 of 9 (56) | 35 of 47 (74) | NS |
| Days to normal CBC | 114 | 84 | — |
All data represent mean values. For acute leukemia, n = 9; for TL, n = 48.
— indicates not applicable.
Represents 9 patients who developed subsequent acute leukemia.
Represents 48 total patients in study.
Symptoms at diagnosis include hepatosplenomegaly, visceral effusions, and infiltrative skin rash (excluding petechiae).
Normalized CBC indicates normalization of complete blood count (ie, normal hemoglobin, WBC count, platelet count, and differential for age).