Genes and polymorphisms
Gene . | Allele* . | Characteristic* . | Context sequence . |
|---|---|---|---|
| Drug metabolic pathways | |||
| CDA | Lys27Gln | Missense change | CAGCTGCTGGTTTGCTCCCAGGAGGCCAAG [A/C] AGTCAGCCTACTGCCCCTACAGTCACT |
| SXR (1) | -1567T>C | UTR 5′ | AATCCAGTATTTCACTTACTCTTTT [C/T] CTTTCCAATATCCTCATGACATTCA |
| SXR (2) | -35C>T | UTR 5′ | AATAAGCTAATACTCCTGTCCTGAA [A/C] AAGGCAGCGGCTCCTTGGTAAAGCT |
| GSTT1 | Ex5-182C>T | UTR 3′ | TGCTCTGGGACTTGGGCAAGTCTTA [G/A] GCAAGCCATTCCTGCTTTCTGGGCC |
| SULT1C2 | Asp5Glu | Missense change | TTCTTACACTAATGGCCTTACACGA [C/G] ATGGAGGATTTTACATTTGATGGAA |
| Multidrug resistance | |||
| MDR1 (1) | Ex29-193C>T | UTR3′ | AAAATTTATAATGCAGTTTAAACTA [C/T] GATTTCTCTCCACTTGATGATGTCT |
| MDR1 (2) | Ilet 144Met | Missense change | TGTTGGCCTCCTTTGCTGCCCTCAC [A/G] ATCTCTTCCTGTGACACCACCCGGC |
| Angiogenesis | |||
| VEGF (1) | Ex7-913A>G | UTR 3′ | CACCTGCTTCTGAGTTGCCCAGGAG [A/G] CCACTGGCAGATGTCCCGGCGAAGA |
| VEGF (2) | -634G>C | UTR 5′ | CGCGCGGGCGTGCGAGCAGCGAAAG [C/G] GACAGGGGCAAAGTGAGTGACCTGC |
| DNA repair | |||
| XPD | Lys751Gln | Nonsense change | GCAGCTAGAATCAGAGGAGACGCTG [C/A] AGAGGATAGAGCAGATTGCTCAGCA |
| XPA | -4A>G | UTR 5′ | GGGAGCTAGGTCCTCGGAGTGGGCC [G/A] GAGATGGCGGCGGCCGACGGGGCTT |
| ERCC1 | Lys259Thr | Missense change | AAGAAGAGGAAGAAGCCCAAAGGGA [A/C] AGAAACCTTCGAGCCAGAAGACAAG |
| ERCC5 | His46His | Silent change | CACTTAAAGGAGTCCGGGATCGCCA [C/T] GGGAACTCAATAGAAAATCCTCATC |
| TOP2A | Ex39-531 G>A | Intron/UTR 3′ | TAGACACAGCCAAAGTGTTTTTCTT [C/T] GGCCTCTGATGATTTGAGAAGATGA |
Gene . | Allele* . | Characteristic* . | Context sequence . |
|---|---|---|---|
| Drug metabolic pathways | |||
| CDA | Lys27Gln | Missense change | CAGCTGCTGGTTTGCTCCCAGGAGGCCAAG [A/C] AGTCAGCCTACTGCCCCTACAGTCACT |
| SXR (1) | -1567T>C | UTR 5′ | AATCCAGTATTTCACTTACTCTTTT [C/T] CTTTCCAATATCCTCATGACATTCA |
| SXR (2) | -35C>T | UTR 5′ | AATAAGCTAATACTCCTGTCCTGAA [A/C] AAGGCAGCGGCTCCTTGGTAAAGCT |
| GSTT1 | Ex5-182C>T | UTR 3′ | TGCTCTGGGACTTGGGCAAGTCTTA [G/A] GCAAGCCATTCCTGCTTTCTGGGCC |
| SULT1C2 | Asp5Glu | Missense change | TTCTTACACTAATGGCCTTACACGA [C/G] ATGGAGGATTTTACATTTGATGGAA |
| Multidrug resistance | |||
| MDR1 (1) | Ex29-193C>T | UTR3′ | AAAATTTATAATGCAGTTTAAACTA [C/T] GATTTCTCTCCACTTGATGATGTCT |
| MDR1 (2) | Ilet 144Met | Missense change | TGTTGGCCTCCTTTGCTGCCCTCAC [A/G] ATCTCTTCCTGTGACACCACCCGGC |
| Angiogenesis | |||
| VEGF (1) | Ex7-913A>G | UTR 3′ | CACCTGCTTCTGAGTTGCCCAGGAG [A/G] CCACTGGCAGATGTCCCGGCGAAGA |
| VEGF (2) | -634G>C | UTR 5′ | CGCGCGGGCGTGCGAGCAGCGAAAG [C/G] GACAGGGGCAAAGTGAGTGACCTGC |
| DNA repair | |||
| XPD | Lys751Gln | Nonsense change | GCAGCTAGAATCAGAGGAGACGCTG [C/A] AGAGGATAGAGCAGATTGCTCAGCA |
| XPA | -4A>G | UTR 5′ | GGGAGCTAGGTCCTCGGAGTGGGCC [G/A] GAGATGGCGGCGGCCGACGGGGCTT |
| ERCC1 | Lys259Thr | Missense change | AAGAAGAGGAAGAAGCCCAAAGGGA [A/C] AGAAACCTTCGAGCCAGAAGACAAG |
| ERCC5 | His46His | Silent change | CACTTAAAGGAGTCCGGGATCGCCA [C/T] GGGAACTCAATAGAAAATCCTCATC |
| TOP2A | Ex39-531 G>A | Intron/UTR 3′ | TAGACACAGCCAAAGTGTTTTTCTT [C/T] GGCCTCTGATGATTTGAGAAGATGA |
NCIB/Celera.