Table 1. Blockade of mTOR and NF-κB... | American Society of Hematology

Table 1.

Blockade of mTOR and NF-κB signaling synergize to effectively inhibit BM-ECs

RAPA, ng/mL	SC-514, μM	CI
Combination A
1.25	9.375	0.411
2.5	18.75	0.423
5	37.5	0.577
10^*	75^*	0.758
Combination B
2.96	29.6	0.352
4.44	44.44	0.472
6.67	66.67	0.630
10^*	100^*	0.762

RAPA, ng/mL	SC-514, μM	CI
Combination A
1.25	9.375	0.411
2.5	18.75	0.423
5	37.5	0.577
10^*	75^*	0.758
Combination B
2.96	29.6	0.352
4.44	44.44	0.472
6.67	66.67	0.630
10^*	100^*	0.762

RAPA indicates rapamycin; CI, combination index.

Highest dose combination