Human brain tissues: clinical and pathologic description
Case . | Neuropathologic alterations . | Proportion of microvessels with disrupted occludin and claudin-5 immunostaining, % . |
|---|---|---|
| 1 | Severe HIVE* | 54 |
| 2 | Severe HIVE | 45 |
| 3 | Severe HIVE | 60 |
| 4 | Severe HIVE | 60 |
| 5 | Moderate HIVE† | 45 |
| 6 | Moderate HIVE | 50 |
| 7 | Mild HIVE‡ | 15 |
| 8 | Mild HIVE | 20 |
| 9 | HIV-1§ | 2 |
| 10 | HIV-1 | 0 |
| 11 | HIV-1 | 0 |
| 12 | HIV-1 | 0 |
| 13 | Control | 0 |
| 14 | Control | 0 |
| 15 | Control | 0 |
| 16 | Control | 0 |
| 17 | Control | 0 |
Case . | Neuropathologic alterations . | Proportion of microvessels with disrupted occludin and claudin-5 immunostaining, % . |
|---|---|---|
| 1 | Severe HIVE* | 54 |
| 2 | Severe HIVE | 45 |
| 3 | Severe HIVE | 60 |
| 4 | Severe HIVE | 60 |
| 5 | Moderate HIVE† | 45 |
| 6 | Moderate HIVE | 50 |
| 7 | Mild HIVE‡ | 15 |
| 8 | Mild HIVE | 20 |
| 9 | HIV-1§ | 2 |
| 10 | HIV-1 | 0 |
| 11 | HIV-1 | 0 |
| 12 | HIV-1 | 0 |
| 13 | Control | 0 |
| 14 | Control | 0 |
| 15 | Control | 0 |
| 16 | Control | 0 |
| 17 | Control | 0 |
Severe HIVE is defined as expression of HLA-DR on 80% to 90% of microglia; HIV-1 infection of ramified microglia; formation of 1 to 2 microglial nodules and 25 to 50 infiltrating macrophages per five × 10-power fields; and abundant multinucleated cells.
Moderate HIVE is defined as expression of HLA-DR on 20% to 70% of microglia; formation of 1 to 2 microglial nodules per ten × 10-power fields and 5 to 25 infiltrating macrophages per five × 10-power fields; and frequent multinucleated giant cells.
Mild HIVE is defined as expression of HLA-DR on 10% to 15% of microglia; 1 microglial nodule per twenty × 10-power fields and 3 to 5 CD68+ infiltrating macrophages per five × 10-power fields; and rare multinucleated cells (as described before33 ).
HIV-1—seropositive patients who died of complications of AIDS not related to the CNS; no changes were seen on neuropathologic examination.