Erythropoiesis and thrombopoiesis in PV and ET
. | PV . | ET . |
|---|---|---|
| Plasma hormone level | ↓ Epo | ↑ Tpo |
| Hormone receptor binding | Normal Epo-R | ↓ Tpo-R (c-Mpl) |
| Epo-independent (endogenous) erythroid colonies | Yes | Yes |
| Tpo-independent megakaryocyte colonies | Yes | Yes |
| Bone marrow hyperplasia | Predominantly erythroid | Predominantly megakaryocytic |
. | PV . | ET . |
|---|---|---|
| Plasma hormone level | ↓ Epo | ↑ Tpo |
| Hormone receptor binding | Normal Epo-R | ↓ Tpo-R (c-Mpl) |
| Epo-independent (endogenous) erythroid colonies | Yes | Yes |
| Tpo-independent megakaryocyte colonies | Yes | Yes |
| Bone marrow hyperplasia | Predominantly erythroid | Predominantly megakaryocytic |