Table 5. Toxicity . FLA vs ADE . . G-CSF... | American Society of Hematology

Table 5.

Toxicity

	FLA vs ADE			G-CSF vs no G-CSF			ATRA vs no ATRA
Toxicity	FLA	ADE	G-CSF	None	ATRA	None
Hematologic^*
Neutrophils
Course 1	22	20	20	24	23	22
Course 2	20	22	21	22	22	21
Platelets
Course 1	33	30	31	32	30	35
Course 2	23	30	30	28	31	29
Nonhematologic†
Nausea/vomiting
Course 1	1.3	1.5	1.2	1.5	1.3	1.3
Course 2	1.0	1.2	1.1	1.2	1.0	1.2
Alopecia
Course 1	2.4	2.7	2.5	2.6	2.6	2.4
Course 2	2.4	2.9	2.7	2.7	2.8	2.6
Oral
Course 1	1.1	1.2	1.1	1.0	1.0	1.2
Course 2	0.8	1.0	1.0	0.8	0.9	0.9
Diarrhea
Course 1	0.8	1.4	1.1	1.1	1.2	0.9
Course 2	0.5	1.0	0.8	0.7	0.9	0.6
Cardiac
Course 1	0.3	0.2	0.3	0.3	0.3	0.2
Course 2	0.2	0.1	0.2	0.1	0.1	0.1

	FLA vs ADE			G-CSF vs no G-CSF			ATRA vs no ATRA
Toxicity	FLA	ADE	G-CSF	None	ATRA	None
Hematologic^*
Neutrophils
Course 1	22	20	20	24	23	22
Course 2	20	22	21	22	22	21
Platelets
Course 1	33	30	31	32	30	35
Course 2	23	30	30	28	31	29
Nonhematologic†
Nausea/vomiting
Course 1	1.3	1.5	1.2	1.5	1.3	1.3
Course 2	1.0	1.2	1.1	1.2	1.0	1.2
Alopecia
Course 1	2.4	2.7	2.5	2.6	2.6	2.4
Course 2	2.4	2.9	2.7	2.7	2.8	2.6
Oral
Course 1	1.1	1.2	1.1	1.0	1.0	1.2
Course 2	0.8	1.0	1.0	0.8	0.9	0.9
Diarrhea
Course 1	0.8	1.4	1.1	1.1	1.2	0.9
Course 2	0.5	1.0	0.8	0.7	0.9	0.6
Cardiac
Course 1	0.3	0.2	0.3	0.3	0.3	0.2
Course 2	0.2	0.1	0.2	0.1	0.1	0.1

Values in the table are median days from end of course to recovery (1.0 × 10⁹/L for neutrophils; 100 × 10⁹/L for platelets).

Mean WHO grade.