Defect of homologous recombination/single-strand annealing in FA cells
. | . | SCE . | . | . | . | |
|---|---|---|---|---|---|---|
| Subtype, cell type . | Efficiency of HR . | Spontaneous . | ICL induced . | SSA . | References . | |
| FA-A | ||||||
| Human FA-A fibroblast (SV40 transformed) | Decreased | NA | NA | Decreased | Nakanishi et al116 | |
| Fanca-/- mouse fibroblast | Decreased | NA | NA | Decreased | Yang et al117 | |
| FA-C | ||||||
| Chicken DT40 | Decreased | Increased | Poor response | NA | Niedzwiedz et al112 | |
| Chicken DT40 | Decreased | Increased | Poor response | NA | Hirano et al20 | |
| Chicken DT40 | Normal | Increased | NA | NA | Bridge et al89 | |
| FA-D1 | ||||||
| Human Capan1 pancreatic cancer (Brca2 mt) | Decreased | NA | NA | NA | Moynahan et al69 | |
| Mouse ES cells with a Brca2 exon 27 deletion | Decreased | NA | NA | Increased | Moynahan et al,69 Stark et al115 | |
| Chinese hamster cell (VC-8) | Decreased | NA | NA | Increased | Nakanishi et al,116 Yang et al117 | |
| FA-D2 | ||||||
| Human FA-D2 fibroblast (SV40 transformed) | Decreased | NA | NA | Decreased | Nakanishi et al116 | |
| Human FA-D2 fibroblast (SV40 transformed) | Normal | NA | NA | NA | Ohashi et al101 | |
| Chicken DT40 | Decreased | Increased | Poor response | NA | Yamamoto et al99 | |
| FA-G | ||||||
| Human FA-G fibroblast (SV40 transformed) | Decreased | NA | NA | Decreased | Nakanishi et al116 | |
| Chicken DT40 | Decreased | NA | NA | NA | Yamamoto et al99 | |
| FA-J | ||||||
| Human MCF7 breast cancer (FANCJ siRNA) | Decreased | NA | NA | NA | Litman et al12 | |
| Chicken DT40 | Normal | Increased | NA | NA | Bridge et al89 | |
| FA-M | ||||||
| Chicken DT40 | Normal | NA | NA | NA | Mosedale et al118 | |
. | . | SCE . | . | . | . | |
|---|---|---|---|---|---|---|
| Subtype, cell type . | Efficiency of HR . | Spontaneous . | ICL induced . | SSA . | References . | |
| FA-A | ||||||
| Human FA-A fibroblast (SV40 transformed) | Decreased | NA | NA | Decreased | Nakanishi et al116 | |
| Fanca-/- mouse fibroblast | Decreased | NA | NA | Decreased | Yang et al117 | |
| FA-C | ||||||
| Chicken DT40 | Decreased | Increased | Poor response | NA | Niedzwiedz et al112 | |
| Chicken DT40 | Decreased | Increased | Poor response | NA | Hirano et al20 | |
| Chicken DT40 | Normal | Increased | NA | NA | Bridge et al89 | |
| FA-D1 | ||||||
| Human Capan1 pancreatic cancer (Brca2 mt) | Decreased | NA | NA | NA | Moynahan et al69 | |
| Mouse ES cells with a Brca2 exon 27 deletion | Decreased | NA | NA | Increased | Moynahan et al,69 Stark et al115 | |
| Chinese hamster cell (VC-8) | Decreased | NA | NA | Increased | Nakanishi et al,116 Yang et al117 | |
| FA-D2 | ||||||
| Human FA-D2 fibroblast (SV40 transformed) | Decreased | NA | NA | Decreased | Nakanishi et al116 | |
| Human FA-D2 fibroblast (SV40 transformed) | Normal | NA | NA | NA | Ohashi et al101 | |
| Chicken DT40 | Decreased | Increased | Poor response | NA | Yamamoto et al99 | |
| FA-G | ||||||
| Human FA-G fibroblast (SV40 transformed) | Decreased | NA | NA | Decreased | Nakanishi et al116 | |
| Chicken DT40 | Decreased | NA | NA | NA | Yamamoto et al99 | |
| FA-J | ||||||
| Human MCF7 breast cancer (FANCJ siRNA) | Decreased | NA | NA | NA | Litman et al12 | |
| Chicken DT40 | Normal | Increased | NA | NA | Bridge et al89 | |
| FA-M | ||||||
| Chicken DT40 | Normal | NA | NA | NA | Mosedale et al118 | |
Efficiency of HR was not reported for the following subtypes: FA-B, FA-E, FA-F, FA-I, and FA-L.
HR indicates homologous recombination; SCE, sister chromatid exchange; SSA, single-strand annealing; NA, not available; ES, embryonic stem.