Abnormalities of FA genes in human cancer in the general population
Gene, type of abnormality, tissue . | Frequency in clinical samples (%) . | Cell lines with FA abnormalities . | Reference . |
|---|---|---|---|
| FANCF | |||
| Methylation | |||
| Ovarian cancer | 4/19 (21) | TOV-21G, 2008, C13*, OAW42 | Taniguchi et al30 |
| Stage III/IV epithelial ovarian tumors | 0/? (0) | NA | Teodoridis et al140 |
| Granulosa cell tumors of the ovary | 6/25 (24) | NA | Dhillon et al35 |
| Breast cancer | 13/75 (17) | NA | Olopade and Wei32 |
| Non-small cell lung cancer | 22/158 (14) | NA | Marsit et al33 |
| Head and neck squamous cell carcinoma | 13/89 (15) | NA | Marsit et al33 |
| Cervical cancer | 27/91 (30) | SiHa, ME-180, SW756 | Narayan et al34 |
| Testicular germ cell tumor (nonseminoma) | 4/60 (6.7) | NA | Koul et al36 |
| Acute myeloid leukemia | 0/36 (0) | CHRF-288 | Tischkowitz et al31 |
| Decreased expression (unknown mechanism) | |||
| Breast cancer | NA | UACC812 | van der Heijden et al141 |
| FANCA | |||
| Reduced expression (heterozygous deletion) | |||
| Acute myeloid leukemia (adult) | 4/101 (4.0) | NA | Tischkowitz et al143 |
| Point mutation | |||
| Acute myeloid leukemia (adult) | 6/79 (7.6) | NA | Condie et al142 |
| Functional abnormality (unknown mechanism) | |||
| Acute myeloid leukemia (adult) | NA | UoC-M1 | Lensch et al144 |
| FANCC | |||
| Point mutation/frameshift + LOH | |||
| Pancreatic cancer | 2/22 (9)* | NA | van der Heijden et al37 |
| Large homozygous deletion | |||
| Pancreatic cancer | NA | PL11 | van der Heijden et al38 |
| FANCG | |||
| Point mutation (nonsense) + LOH | |||
| Pancreatic cancer | 0/22 (0)† | Hs766T | van der Heijden et al37 |
| Unknown | |||
| Lack of monoubiquitination of FANCD2 | |||
| Head and neck squamous cell carcinoma | NA | FaDu | van der Heijden et al141 |
Gene, type of abnormality, tissue . | Frequency in clinical samples (%) . | Cell lines with FA abnormalities . | Reference . |
|---|---|---|---|
| FANCF | |||
| Methylation | |||
| Ovarian cancer | 4/19 (21) | TOV-21G, 2008, C13*, OAW42 | Taniguchi et al30 |
| Stage III/IV epithelial ovarian tumors | 0/? (0) | NA | Teodoridis et al140 |
| Granulosa cell tumors of the ovary | 6/25 (24) | NA | Dhillon et al35 |
| Breast cancer | 13/75 (17) | NA | Olopade and Wei32 |
| Non-small cell lung cancer | 22/158 (14) | NA | Marsit et al33 |
| Head and neck squamous cell carcinoma | 13/89 (15) | NA | Marsit et al33 |
| Cervical cancer | 27/91 (30) | SiHa, ME-180, SW756 | Narayan et al34 |
| Testicular germ cell tumor (nonseminoma) | 4/60 (6.7) | NA | Koul et al36 |
| Acute myeloid leukemia | 0/36 (0) | CHRF-288 | Tischkowitz et al31 |
| Decreased expression (unknown mechanism) | |||
| Breast cancer | NA | UACC812 | van der Heijden et al141 |
| FANCA | |||
| Reduced expression (heterozygous deletion) | |||
| Acute myeloid leukemia (adult) | 4/101 (4.0) | NA | Tischkowitz et al143 |
| Point mutation | |||
| Acute myeloid leukemia (adult) | 6/79 (7.6) | NA | Condie et al142 |
| Functional abnormality (unknown mechanism) | |||
| Acute myeloid leukemia (adult) | NA | UoC-M1 | Lensch et al144 |
| FANCC | |||
| Point mutation/frameshift + LOH | |||
| Pancreatic cancer | 2/22 (9)* | NA | van der Heijden et al37 |
| Large homozygous deletion | |||
| Pancreatic cancer | NA | PL11 | van der Heijden et al38 |
| FANCG | |||
| Point mutation (nonsense) + LOH | |||
| Pancreatic cancer | 0/22 (0)† | Hs766T | van der Heijden et al37 |
| Unknown | |||
| Lack of monoubiquitination of FANCD2 | |||
| Head and neck squamous cell carcinoma | NA | FaDu | van der Heijden et al141 |