Altered TGF-β signaling in hematalogic malignancies
Disease and alterations in the TGF-β signaling pathway . | Reference . |
|---|---|
| AML-M2 | |
| AML1/ETO blocks Smad3 DNA binding | Jakubowiak et al47 |
| AML-M3 | |
| PML-RARα blocks phosphorylation of Smad2/3 | Lin et al49 |
| AML | |
| Dominant negative mutations in Smad4 | Imai et al50 |
| Hypomorphic TβRI polymorphism, TβRI(6A) | Pasche et al51 |
| CML | |
| Evi-1 overexpression blocks Smad3 DNA binding, recruits corepressor | Kurokawa et al43 |
| AML1/EVI-1 blocks Smad3 DNA binding, recruits corepressor | Kurokawa et al54 |
| Childhood T-cell ALL | |
| Decreased Smad3 protein expression | Wolfraim et al55 |
| Adult T-cell ALL | |
| HTLV-1 Tax inhibits coactivator CBP/p300, blocks Smad2/3/4 formation, inhibits Smad3 DNA binding | Mori et al44 , Lee et al56 , Arnulf et al57 |
| CLL | |
| Decreased TβRI expression | DeCoteau et al74 , Lagneaux et al84 |
| TβRI mutation (Leu12Gln with single in-frame Ala deletion) | Schiemann et al75 |
| Increased TβRIII expression | Klein et al12 , Jelinkek et al13 |
| Hairy-cell leukemia | |
| Increased TGF-β production enhances bone marrow fibrosis | Shehata et al76 |
| Polycythemia vera | |
| Decreased TβRII expression | Rooke et al61 |
| Essential thrombocythemia | |
| Decreased Smad4 expression | Kuroda et al60 |
| Decreased TβRII expression | Rooke et al61 |
| NHL | |
| Reduced TβRI and TβRII expression | Capocasale et al66 , Schiemann et al69 |
| Dominant negative mutation of TβRII (D404G) | Knaus et al67 |
| Multiple myeloma | |
| Deficient trafficking of TGF-β receptors to the cell surface | Fernandez et al83 |
Disease and alterations in the TGF-β signaling pathway . | Reference . |
|---|---|
| AML-M2 | |
| AML1/ETO blocks Smad3 DNA binding | Jakubowiak et al47 |
| AML-M3 | |
| PML-RARα blocks phosphorylation of Smad2/3 | Lin et al49 |
| AML | |
| Dominant negative mutations in Smad4 | Imai et al50 |
| Hypomorphic TβRI polymorphism, TβRI(6A) | Pasche et al51 |
| CML | |
| Evi-1 overexpression blocks Smad3 DNA binding, recruits corepressor | Kurokawa et al43 |
| AML1/EVI-1 blocks Smad3 DNA binding, recruits corepressor | Kurokawa et al54 |
| Childhood T-cell ALL | |
| Decreased Smad3 protein expression | Wolfraim et al55 |
| Adult T-cell ALL | |
| HTLV-1 Tax inhibits coactivator CBP/p300, blocks Smad2/3/4 formation, inhibits Smad3 DNA binding | Mori et al44 , Lee et al56 , Arnulf et al57 |
| CLL | |
| Decreased TβRI expression | DeCoteau et al74 , Lagneaux et al84 |
| TβRI mutation (Leu12Gln with single in-frame Ala deletion) | Schiemann et al75 |
| Increased TβRIII expression | Klein et al12 , Jelinkek et al13 |
| Hairy-cell leukemia | |
| Increased TGF-β production enhances bone marrow fibrosis | Shehata et al76 |
| Polycythemia vera | |
| Decreased TβRII expression | Rooke et al61 |
| Essential thrombocythemia | |
| Decreased Smad4 expression | Kuroda et al60 |
| Decreased TβRII expression | Rooke et al61 |
| NHL | |
| Reduced TβRI and TβRII expression | Capocasale et al66 , Schiemann et al69 |
| Dominant negative mutation of TβRII (D404G) | Knaus et al67 |
| Multiple myeloma | |
| Deficient trafficking of TGF-β receptors to the cell surface | Fernandez et al83 |
TGF-β indicates transforming growth factor-β.