Contraindications to specific antithrombotic therapies in infants and children
Unfractionated heparin |
| Known allergy |
| History of HITs |
| Low-molecular-weight heparin |
| Known allergy |
| History of HITs |
| Invasive procedure within the previous 24 h |
| Systemic TPA |
| Known allergy |
| Active bleeding |
| Central nervous system ischemia/hemorrhage/surgery within the previous 10 d (includes birth asphyxia) |
| Surgery within the previous 7 d |
| Invasive procedure within the previous 3 d |
| Seizures within the previous 48 h |
| Thrombolysis by interventional radiology |
| Known allergy |
| In cases where needed, inability to place a vena cava filter |
| Limitations are size of involved vessels and experience of interventionalists |
Unfractionated heparin |
| Known allergy |
| History of HITs |
| Low-molecular-weight heparin |
| Known allergy |
| History of HITs |
| Invasive procedure within the previous 24 h |
| Systemic TPA |
| Known allergy |
| Active bleeding |
| Central nervous system ischemia/hemorrhage/surgery within the previous 10 d (includes birth asphyxia) |
| Surgery within the previous 7 d |
| Invasive procedure within the previous 3 d |
| Seizures within the previous 48 h |
| Thrombolysis by interventional radiology |
| Known allergy |
| In cases where needed, inability to place a vena cava filter |
| Limitations are size of involved vessels and experience of interventionalists |