Table 4. Twenty-five most significant... | American Society of Hematology

Table 4.

Twenty-five most significant probe sets representing 20 genes identified by MAS 5.0, dChip, and RMA

Greater expression by disease phenotype	Common name	Affymetrix accession no.	GenBank accession no.	Description
Agg	CD7	214049_x_at	AI829961	CD7 antigen (p41)
Agg	CD7	214551_s_at	NM_006137	CD7 antigen (p41)
Agg	SMA4	215599_at	NM_021652	Spinal muscular atrophy gene 4
Agg	HIST1H2BG	215779_s_at	NM_003518	H2B histone family, member A
Agg	HIST1H2BG	210387_at	BC001131	H2B histone family, member A
Ind	EDN	206111_at	NM_002934	Eosinophil-derived neurotoxin
Ind	ECP	206851_at	NM_002935	Eosinophil cationic protein
Ind	MBP	211743_s_at	NM_002728	Eosinophil granule major basic protein
Ind	STARD1	204548_at	NM_000349	Steroidogenic acute regulatory protein
Ind	CXCR4	209201_x_at	L01639	Chemokine (C-X-C motif), receptor 4 (fusin)
Ind	CXCR4	211919_s_at	AF348491	Chemokine (C-X-C motif), receptor 4 (fusin)
Ind	CXCR4	217028_at	AJ224869	Chemokine (C-X-C motif), receptor 4 (fusin)
Ind	HTM4	210254_at	NM_006138	Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell–specific)
Ind	HM74	205220_at	NM_006018	Nicotinic acid receptor; GTP-binding protein
Ind	AZU1	214575_s_at	NM_001700	Azurocidin 1
Ind	PR-3	207341_at	NM_002777	Proteinase 3
Ind	ELA2	206871_at	NM_001972	Elastase 2
Ind	GFI1	206589_at	NM_005263	Growth factor independent 1
Ind	CG	205653_at	NM_001911	Cathepsin G
Ind	DF	205382_s_at	NM_001928	D component of complement (adipsin)
Ind	MPO	203949_at	NM_000250	Myeloperoxidase
Ind	MPO	203948_s_at	J02694	Myeloperoxidase
Ind	CEBPA	204039_at^*	NM_004364	CCAAT/enhancer binding protein, alpha
Ind	CLC	206207_at^*	NM_001828.3	Charcot-Leyden crystal protein
Ind	FUT4	209893_s_at†	NM_002033	Fucosyltransferase 4

Greater expression by disease phenotype	Common name	Affymetrix accession no.	GenBank accession no.	Description
Agg	CD7	214049_x_at	AI829961	CD7 antigen (p41)
Agg	CD7	214551_s_at	NM_006137	CD7 antigen (p41)
Agg	SMA4	215599_at	NM_021652	Spinal muscular atrophy gene 4
Agg	HIST1H2BG	215779_s_at	NM_003518	H2B histone family, member A
Agg	HIST1H2BG	210387_at	BC001131	H2B histone family, member A
Ind	EDN	206111_at	NM_002934	Eosinophil-derived neurotoxin
Ind	ECP	206851_at	NM_002935	Eosinophil cationic protein
Ind	MBP	211743_s_at	NM_002728	Eosinophil granule major basic protein
Ind	STARD1	204548_at	NM_000349	Steroidogenic acute regulatory protein
Ind	CXCR4	209201_x_at	L01639	Chemokine (C-X-C motif), receptor 4 (fusin)
Ind	CXCR4	211919_s_at	AF348491	Chemokine (C-X-C motif), receptor 4 (fusin)
Ind	CXCR4	217028_at	AJ224869	Chemokine (C-X-C motif), receptor 4 (fusin)
Ind	HTM4	210254_at	NM_006138	Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell–specific)
Ind	HM74	205220_at	NM_006018	Nicotinic acid receptor; GTP-binding protein
Ind	AZU1	214575_s_at	NM_001700	Azurocidin 1
Ind	PR-3	207341_at	NM_002777	Proteinase 3
Ind	ELA2	206871_at	NM_001972	Elastase 2
Ind	GFI1	206589_at	NM_005263	Growth factor independent 1
Ind	CG	205653_at	NM_001911	Cathepsin G
Ind	DF	205382_s_at	NM_001928	D component of complement (adipsin)
Ind	MPO	203949_at	NM_000250	Myeloperoxidase
Ind	MPO	203948_s_at	J02694	Myeloperoxidase
Ind	CEBPA	204039_at^*	NM_004364	CCAAT/enhancer binding protein, alpha
Ind	CLC	206207_at^*	NM_001828.3	Charcot-Leyden crystal protein
Ind	FUT4	209893_s_at†	NM_002033	Fucosyltransferase 4

Agg indicates aggressive CML; Ind, indolent CML.

Probe sets with single nucleotide mismatch according to RefSeq in 2 of 11 probe sequences

†

FUT4 has 2 probe sets in the array; the other probe set 209892_at was only significantly different by dChip and RMA

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