Table 2. Correlation of caspase-3... | American Society of Hematology

Table 2.

Correlation of caspase-3 activation with cytochrome c release in different clinical response groups

Group	Cytochrome c release, total	Cytochrome c release, caspase dependent	Cytochrome c release, caspase independent
Total
r_s	-0.290*	0.361*	-0.019
P	.010	.001	.870
Day 8, prednisone response
Good
r_s	0.295*	0.428*	0.009
P	.016	<.001	.942
Poor
r_s	0.308	-0.065	0.258
P	.330	.840	.418
Day 15, blast cell persistence
Less than 5%
r_s	-0.441*	0.502*	-0.050
P	.007	.002	.772
More than 5%
r_s	-0.256	-0.020	-0.288
P	.198	.922	.146
Day 33, remission
Yes
r_s	-0.274*	0.375*	-0.012
P	.018	.001	.921
No
r_s	-0.400	-0.200	-0.800
P	.600	.800	.200
Relapse
No
r_s	-0.307*	0.375*	-0.022
P	.016	.003	.866
Yes
r_s	-0.275	0.379	-0.177
P	.286	.133	.497

Group	Cytochrome c release, total	Cytochrome c release, caspase dependent	Cytochrome c release, caspase independent
Total
r_s	-0.290*	0.361*	-0.019
P	.010	.001	.870
Day 8, prednisone response
Good
r_s	0.295*	0.428*	0.009
P	.016	<.001	.942
Poor
r_s	0.308	-0.065	0.258
P	.330	.840	.418
Day 15, blast cell persistence
Less than 5%
r_s	-0.441*	0.502*	-0.050
P	.007	.002	.772
More than 5%
r_s	-0.256	-0.020	-0.288
P	.198	.922	.146
Day 33, remission
Yes
r_s	-0.274*	0.375*	-0.012
P	.018	.001	.921
No
r_s	-0.400	-0.200	-0.800
P	.600	.800	.200
Relapse
No
r_s	-0.307*	0.375*	-0.022
P	.016	.003	.866
Yes
r_s	-0.275	0.379	-0.177
P	.286	.133	.497

Total n = 78. On day 8, for patients with good prednisone response, n = 66; with poor response, n = 12. On day 15, for patients with less than 5% blast cell persistence, n = 36; for more than 5% persistence, n = 27. On day 33, for patients in remission, n = 74; for patients not in remission, n = 4. For patients not experiencing relapse, n = 61; for those with relapse, n = 17.

r_s indicates correlation coefficient; P, significance.

Correlation is significant (2-tailed).

View Large

This Feature Is Available To Subscribers Only