Effect of KLF2 on the expression of endothelial lineage markers
Gene symbol . | Gene description* . | Fold change . | P . |
|---|---|---|---|
| ANGPT1 | Angiopoietin 1, transcript variant 1 | 1.05 | .93 |
| ANGPT2 | Angiopoietin 2 | -1.14 | .65 |
| BMP2 | Bone morphogenetic protein 2 | -1.42 | < .001 |
| BMPER | BMP-binding endothelial regulator precursor protein | 1.02 | .75 |
| BMPRIA | Bone morphogenetic protein receptor, type IA | 1.46 | < .001 |
| CD34 | CD34 antigen | 1.06 | .60 |
| CDH5 | VE-cadherin (vascular endothelium) | -1.08 | .56 |
| CLDN5 | Claudin 5 | -1.08 | .37 |
| EDG1-7 | Endothelial differentiation G-protein—coupled receptors 1-7 | -1.3-1.5 | .008-.9 |
| EFNA1-5 | Ephrin-A1, A2, A3, A4, A5 | -1.7-1.1 | < .001-.9 |
| EFNB1-3 | Ephrin-B1, B2, B3 | -1.3-1.5 | .002-.1 |
| ENG | Endoglin (Osler-Rendu-Weber syndrome 1) | 1.30 | .001 |
| EPHB4 | Ephrin receptor B4 | 1.52 | < .001 |
| FLT1 | Vascular endothelial growth factor receptor-1 (VEGFR1/Flt) | 1.40 | < .001 |
| FZD4 | Frizzled homolog 4 (Drosophila) | -1.25 | .012 |
| GJA4 | Gap junction protein alpha 4 (connexin 37) | -1.46 | < .001 |
| HEY1 | Hairy/enhancer-of-split related with YRPW motif 1 | -1.03 | .74 |
| HEY2 | Hairy/enhancer-of-split related with YRPW motif 2 | -1.01 | .90 |
| JAG2 | Jagged 2, transcript variant 1 | -1.90 | < .001 |
| KDR | Vascular endothelial growth factor receptor-2 (VEGFR2/KDR/Flk-1) | -2.61 | < .001 |
| NOTCH1 | Homolog of Drosophila Notch (TAN1) | 1.09 | .39 |
| NOTCH2 | Homolog of Drosophila Notch | 1.14 | .044 |
| NOTCH3 | Homolog of Drosophila Notch | -1.32 | .002 |
| NOTCH4 | Homolog of Drosophila Notch (INT3) | -1.45 | < .001 |
| NRP1 | Neuropilin 1 | -1.44 | .029 |
| NUMB | Numb homolog (Drosophila) | -1.07 | .36 |
| PECAM1 | Platelet/endothelial cell adhesion molecule (CD31) | 1.11 | .22 |
| PROM1 | Prominin 1 | 1.13 | .16 |
| SEMA3C | Semaphorin 3C | 1.10 | .16 |
| SIAH1 | Seven in absentia homolog 1 (Drosophila) | -1.15 | .065 |
| TIE | Tyrosine kinase with immunoglobulin and EGF homology domains | -1.00 | .96 |
Gene symbol . | Gene description* . | Fold change . | P . |
|---|---|---|---|
| ANGPT1 | Angiopoietin 1, transcript variant 1 | 1.05 | .93 |
| ANGPT2 | Angiopoietin 2 | -1.14 | .65 |
| BMP2 | Bone morphogenetic protein 2 | -1.42 | < .001 |
| BMPER | BMP-binding endothelial regulator precursor protein | 1.02 | .75 |
| BMPRIA | Bone morphogenetic protein receptor, type IA | 1.46 | < .001 |
| CD34 | CD34 antigen | 1.06 | .60 |
| CDH5 | VE-cadherin (vascular endothelium) | -1.08 | .56 |
| CLDN5 | Claudin 5 | -1.08 | .37 |
| EDG1-7 | Endothelial differentiation G-protein—coupled receptors 1-7 | -1.3-1.5 | .008-.9 |
| EFNA1-5 | Ephrin-A1, A2, A3, A4, A5 | -1.7-1.1 | < .001-.9 |
| EFNB1-3 | Ephrin-B1, B2, B3 | -1.3-1.5 | .002-.1 |
| ENG | Endoglin (Osler-Rendu-Weber syndrome 1) | 1.30 | .001 |
| EPHB4 | Ephrin receptor B4 | 1.52 | < .001 |
| FLT1 | Vascular endothelial growth factor receptor-1 (VEGFR1/Flt) | 1.40 | < .001 |
| FZD4 | Frizzled homolog 4 (Drosophila) | -1.25 | .012 |
| GJA4 | Gap junction protein alpha 4 (connexin 37) | -1.46 | < .001 |
| HEY1 | Hairy/enhancer-of-split related with YRPW motif 1 | -1.03 | .74 |
| HEY2 | Hairy/enhancer-of-split related with YRPW motif 2 | -1.01 | .90 |
| JAG2 | Jagged 2, transcript variant 1 | -1.90 | < .001 |
| KDR | Vascular endothelial growth factor receptor-2 (VEGFR2/KDR/Flk-1) | -2.61 | < .001 |
| NOTCH1 | Homolog of Drosophila Notch (TAN1) | 1.09 | .39 |
| NOTCH2 | Homolog of Drosophila Notch | 1.14 | .044 |
| NOTCH3 | Homolog of Drosophila Notch | -1.32 | .002 |
| NOTCH4 | Homolog of Drosophila Notch (INT3) | -1.45 | < .001 |
| NRP1 | Neuropilin 1 | -1.44 | .029 |
| NUMB | Numb homolog (Drosophila) | -1.07 | .36 |
| PECAM1 | Platelet/endothelial cell adhesion molecule (CD31) | 1.11 | .22 |
| PROM1 | Prominin 1 | 1.13 | .16 |
| SEMA3C | Semaphorin 3C | 1.10 | .16 |
| SIAH1 | Seven in absentia homolog 1 (Drosophila) | -1.15 | .065 |
| TIE | Tyrosine kinase with immunoglobulin and EGF homology domains | -1.00 | .96 |
Endothelial lineage marker genes were obtained from several review papers.22,23