KLF2-responsive genes assigned to the principal categories of endothelial function
Functional category and gene symbols . | Fold change* . |
|---|---|
| Cell migration | |
| ADAM15 | 4.1 |
| CCL2 | -15.4 |
| CCR8 | 2.0 |
| CXCR4 | -1.9 |
| EDN1 | -5.3 |
| HPSE | 3.5 |
| ID1 | 2.6 |
| ID3 | -3.1 |
| IGF2 | 4.1 |
| IL8 | -2.9 |
| KDR | -2.6 |
| NOS3 | 2.7 |
| PTHLH | 7.5 |
| SEMA3F | 6.6 |
| SERPINE1 | -7.4 |
| THBS1 | -7.8 |
| Angiogenesis, vascularization, and development of the artery | |
| BMP4 | -2.7 |
| CCL2 | -15.4 |
| CTGF | -2.8 |
| ECM1 | 2.8 |
| FGF5 | -2.5 |
| HPSE | 3.5 |
| ID1 | 2.6 |
| ID3 | -3.1 |
| IL8 | -2.9 |
| ITGB5 | 3.2 |
| KDR | -2.6 |
| NOS3 | 2.7 |
| PPAP2B | 2.6 |
| PTHLH | 7.5 |
| PTPRJ | 3.3 |
| SEMA3F | 6.6 |
| SERPINE1 | -7.4 |
| THBS1 | -7.8 |
| TIMP1 | 2.7 |
| Vasomotor and blood pressure regulation | |
| ACE | -3.0 |
| ADM | -7.7 |
| AGTRL1 | 3.4 |
| APLN | -2.4 |
| EDN1 | -5.3 |
| NOS3 | 2.7 |
| PTHLH | 7.5 |
| Immune and lymphatic system development and function | |
| BMP4 | -2.7 |
| CIQR1 | -4.4 |
| CCL2 | -15.4 |
| CCND3 | 1.9 |
| CRP | -2.2 |
| CXCR4 | -1.9 |
| DLL1 | 2.2 |
| DOCK2 | -1.9 |
| EDN1 | -5.3 |
| FGR | 2.0 |
| ICOSL | -2.7 |
| ID1 | 2.6 |
| ID3 | -3.1 |
| IGF2 | 4.1 |
| ILIRL1 | 2.6 |
| IL8 | -2.9 |
| KCNN4 | 6.4 |
| KITLG | 3.5 |
| LBP | -2.2 |
| LGALS9 | 2.6 |
| LTC4S | 5.2 |
| MAPK9 | 3.0 |
| MVP | 2.0 |
| NDRG1 | 5.9 |
| NOS3 | 2.7 |
| PROS1 | 2.0 |
| PTPRJ | 3.3 |
| SFTPD | 5.7 |
| STAT1 | -2.1 |
| THBD | 6.1 |
| THBS1 | -7.8 |
| TRAF6 | -2.2 |
| Chemotaxis and infiltration of leukocytes, granulocytes, and lymphocytes | |
| CCL2 | -15.4 |
| CCR8 | 2.0 |
| CRP | -2.2 |
| CXCR4 | -1.9 |
| DAF | 2.0 |
| DOCK2 | -1.9 |
| ELN | 6.1 |
| ILIRL1 | 2.6 |
| IL8 | -2.9 |
| KITLG | 3.5 |
| LGALS9 | 2.6 |
| NFKBIA | 1.9 |
| NOS3 | 2.7 |
| RGS3 | -2.4 |
| SFTPD | 5.7 |
| THBS1 | -7.8 |
| Hemostasis and hematologic disorder | |
| BCL3 | 1.9 |
| CCR8 | 2.0 |
| CXCR4 | -1.9 |
| EPAS1 | 2.1 |
| IGF2 | 4.1 |
| ILIRL1 | 2.6 |
| IL8 | -2.9 |
| KITLG | 3.5 |
| LEPR | -1.9 |
| MT2A | -2.2 |
| NFKBIA | 1.9 |
| PROS1 | 2.0 |
| PTHLH | 7.5 |
| SERPINE1 | -7.4 |
| TFP1 | -1.9 |
| THBD | 6.1 |
| VWF | 2.5 |
Functional category and gene symbols . | Fold change* . |
|---|---|
| Cell migration | |
| ADAM15 | 4.1 |
| CCL2 | -15.4 |
| CCR8 | 2.0 |
| CXCR4 | -1.9 |
| EDN1 | -5.3 |
| HPSE | 3.5 |
| ID1 | 2.6 |
| ID3 | -3.1 |
| IGF2 | 4.1 |
| IL8 | -2.9 |
| KDR | -2.6 |
| NOS3 | 2.7 |
| PTHLH | 7.5 |
| SEMA3F | 6.6 |
| SERPINE1 | -7.4 |
| THBS1 | -7.8 |
| Angiogenesis, vascularization, and development of the artery | |
| BMP4 | -2.7 |
| CCL2 | -15.4 |
| CTGF | -2.8 |
| ECM1 | 2.8 |
| FGF5 | -2.5 |
| HPSE | 3.5 |
| ID1 | 2.6 |
| ID3 | -3.1 |
| IL8 | -2.9 |
| ITGB5 | 3.2 |
| KDR | -2.6 |
| NOS3 | 2.7 |
| PPAP2B | 2.6 |
| PTHLH | 7.5 |
| PTPRJ | 3.3 |
| SEMA3F | 6.6 |
| SERPINE1 | -7.4 |
| THBS1 | -7.8 |
| TIMP1 | 2.7 |
| Vasomotor and blood pressure regulation | |
| ACE | -3.0 |
| ADM | -7.7 |
| AGTRL1 | 3.4 |
| APLN | -2.4 |
| EDN1 | -5.3 |
| NOS3 | 2.7 |
| PTHLH | 7.5 |
| Immune and lymphatic system development and function | |
| BMP4 | -2.7 |
| CIQR1 | -4.4 |
| CCL2 | -15.4 |
| CCND3 | 1.9 |
| CRP | -2.2 |
| CXCR4 | -1.9 |
| DLL1 | 2.2 |
| DOCK2 | -1.9 |
| EDN1 | -5.3 |
| FGR | 2.0 |
| ICOSL | -2.7 |
| ID1 | 2.6 |
| ID3 | -3.1 |
| IGF2 | 4.1 |
| ILIRL1 | 2.6 |
| IL8 | -2.9 |
| KCNN4 | 6.4 |
| KITLG | 3.5 |
| LBP | -2.2 |
| LGALS9 | 2.6 |
| LTC4S | 5.2 |
| MAPK9 | 3.0 |
| MVP | 2.0 |
| NDRG1 | 5.9 |
| NOS3 | 2.7 |
| PROS1 | 2.0 |
| PTPRJ | 3.3 |
| SFTPD | 5.7 |
| STAT1 | -2.1 |
| THBD | 6.1 |
| THBS1 | -7.8 |
| TRAF6 | -2.2 |
| Chemotaxis and infiltration of leukocytes, granulocytes, and lymphocytes | |
| CCL2 | -15.4 |
| CCR8 | 2.0 |
| CRP | -2.2 |
| CXCR4 | -1.9 |
| DAF | 2.0 |
| DOCK2 | -1.9 |
| ELN | 6.1 |
| ILIRL1 | 2.6 |
| IL8 | -2.9 |
| KITLG | 3.5 |
| LGALS9 | 2.6 |
| NFKBIA | 1.9 |
| NOS3 | 2.7 |
| RGS3 | -2.4 |
| SFTPD | 5.7 |
| THBS1 | -7.8 |
| Hemostasis and hematologic disorder | |
| BCL3 | 1.9 |
| CCR8 | 2.0 |
| CXCR4 | -1.9 |
| EPAS1 | 2.1 |
| IGF2 | 4.1 |
| ILIRL1 | 2.6 |
| IL8 | -2.9 |
| KITLG | 3.5 |
| LEPR | -1.9 |
| MT2A | -2.2 |
| NFKBIA | 1.9 |
| PROS1 | 2.0 |
| PTHLH | 7.5 |
| SERPINE1 | -7.4 |
| TFP1 | -1.9 |
| THBD | 6.1 |
| VWF | 2.5 |
Fold change in the average micro array hybridization signal intensities (n=10) of Lenti-KLF2- over Lenti-mock-transduced HUVECs (P < .01).