Treatment options for PTLD
Reduce tumor cell mass (standard treatments) |
| CD20 monoclonal antibody |
| Surgery |
| Chemotherapy |
| Radiotherapy |
| Increase cytotoxic T lymphocyte (CTL) activity |
| Reduction of immunosuppression (standard treatment in SOT) |
| T-cell therapy* using |
| Donor CTLs (SCT) |
| Autologous CTLs |
| Allogeneic CTLs |
| Cytokines* |
| Reduce/eradicate EBV infection (controversial/experimental treatments) |
| Antiviral agents |
| Hydroxyurea |
| Induction of EBV lytic cycle |
| Information was adapted from Gottschalk et al.69 |
Reduce tumor cell mass (standard treatments) |
| CD20 monoclonal antibody |
| Surgery |
| Chemotherapy |
| Radiotherapy |
| Increase cytotoxic T lymphocyte (CTL) activity |
| Reduction of immunosuppression (standard treatment in SOT) |
| T-cell therapy* using |
| Donor CTLs (SCT) |
| Autologous CTLs |
| Allogeneic CTLs |
| Cytokines* |
| Reduce/eradicate EBV infection (controversial/experimental treatments) |
| Antiviral agents |
| Hydroxyurea |
| Induction of EBV lytic cycle |
| Information was adapted from Gottschalk et al.69 |
Treatments are under trial