JAK2V617F mutation status of 2 sibling pairs with familial MPD
Characteristic . | Sibling A11 . | Sibling A12 . | Sibling B11 . | Sibling B12 . |
|---|---|---|---|---|
| Diagnosis | PV | ET | PPVMF | PETMF |
| JAK2V617F | ||||
| Granulocytes | Positive | Negative | Positive | Negative |
| Buccal swab | Positive | Negative | ND | ND |
| Age, y | 47 | 44 | 67 | 74 |
| Sex | M | M | M | M |
| Symptomatic disease | No | No | Yes | Yes |
| Hb level, g/L | 176 | 161 | 118 | 83 |
| WBC count, × 109/L | 8.0 | 19.2 | 36.9 | 1.6 |
| Platelet count, × 109/L | 329 | 660 | 218 | 231 |
| Splenomegaly | + | + | + | + |
Characteristic . | Sibling A11 . | Sibling A12 . | Sibling B11 . | Sibling B12 . |
|---|---|---|---|---|
| Diagnosis | PV | ET | PPVMF | PETMF |
| JAK2V617F | ||||
| Granulocytes | Positive | Negative | Positive | Negative |
| Buccal swab | Positive | Negative | ND | ND |
| Age, y | 47 | 44 | 67 | 74 |
| Sex | M | M | M | M |
| Symptomatic disease | No | No | Yes | Yes |
| Hb level, g/L | 176 | 161 | 118 | 83 |
| WBC count, × 109/L | 8.0 | 19.2 | 36.9 | 1.6 |
| Platelet count, × 109/L | 329 | 660 | 218 | 231 |
| Splenomegaly | + | + | + | + |
Hb indicates hemoglobin; WBC, white blood cell; PV, polycythemia vera; ET, essential thrombocythemia; PPVMF, postpolycythemic myelofibrosis; PETMF, postthrombocythemic myelofibrosis; ND, not done; M, male; and +, present.