Frequencies of TNFA genotypes according to severity and inhibitor status
. | Severe hemophilia A, no. patients (%) . | . | Moderate/mild hemophilia A, no. patients (%) . | . | Total no. patients (%) . | ||
|---|---|---|---|---|---|---|---|
| Genotypes . | Inhibitor positive . | Inhibitor negative . | Inhibitor positive . | Inhibitor negative . | . | ||
| TNFA -827 | |||||||
| -827 C/C | 52 (82.5) | 50 (83.3) | 12 (85.7) | 21 (80.8) | 135 (82.8) | ||
| -827 C/T | 11 (17.5) | 10 (16.7) | 2 (14.3) | 5 (19.2) | 28 (17.2) | ||
| Total | 63 | 60* | 14 | 26 | 163 | ||
| TNFA -308 | |||||||
| -308 G/G | 24 (38.1) | 33 (54.1) | 7 (50.0) | 14 (53.8) | 78 (47.6) | ||
| -308 G/A | 25 (39.7) | 27 (44.3) | 5 (35.7) | 7 (26.9) | 64 (39.0) | ||
| -308 A/A | 14 (22.2)† | 1 (1.6) | 2 (14.3) | 5 (19.2) | 22 (13.4) | ||
| Total | 63 | 61 | 14 | 26 | 164 | ||
| TNFA -238 | |||||||
| -238 G/G | 55 (88.7) | 55 (90.2) | 11 (78.6) | 23 (88.5) | 144 (88.3) | ||
| -238 A/G | 7 (11.3) | 6 (9.8) | 3 (21.4) | 3 (11.5) | 19 (11.7) | ||
| Total | 62* | 61 | 14 | 26 | 163 | ||
| TNFA 670 | |||||||
| 670 A/A | 52 (82.5) | 54 (88.5) | 11 (78.6) | 19 (73.1) | 136 (82.9) | ||
| 670 A/G | 11 (17.5) | 7 (11.5) | 3 (21.4) | 7 (26.9) | 28 (17.1) | ||
| Total | 63 | 61 | 14 | 26 | 164 | ||
| Haplotypes | |||||||
| 2-2 | 13 (20.6) | 1 (1.6) | 1 (7.1) | 3 (11.5) | 18 (11.0) | ||
| 2-X | 21 (33.3) | 25 (41.0) | 4 (28.6) | 6 (23.1) | 56 (34.1) | ||
| X-X | 29 (46.0) | 35 (57.4) | 9 (64.3) | 17 (65.4) | 90 (54.9) | ||
| Total | 63 | 61 | 14 | 26 | 164 | ||
. | Severe hemophilia A, no. patients (%) . | . | Moderate/mild hemophilia A, no. patients (%) . | . | Total no. patients (%) . | ||
|---|---|---|---|---|---|---|---|
| Genotypes . | Inhibitor positive . | Inhibitor negative . | Inhibitor positive . | Inhibitor negative . | . | ||
| TNFA -827 | |||||||
| -827 C/C | 52 (82.5) | 50 (83.3) | 12 (85.7) | 21 (80.8) | 135 (82.8) | ||
| -827 C/T | 11 (17.5) | 10 (16.7) | 2 (14.3) | 5 (19.2) | 28 (17.2) | ||
| Total | 63 | 60* | 14 | 26 | 163 | ||
| TNFA -308 | |||||||
| -308 G/G | 24 (38.1) | 33 (54.1) | 7 (50.0) | 14 (53.8) | 78 (47.6) | ||
| -308 G/A | 25 (39.7) | 27 (44.3) | 5 (35.7) | 7 (26.9) | 64 (39.0) | ||
| -308 A/A | 14 (22.2)† | 1 (1.6) | 2 (14.3) | 5 (19.2) | 22 (13.4) | ||
| Total | 63 | 61 | 14 | 26 | 164 | ||
| TNFA -238 | |||||||
| -238 G/G | 55 (88.7) | 55 (90.2) | 11 (78.6) | 23 (88.5) | 144 (88.3) | ||
| -238 A/G | 7 (11.3) | 6 (9.8) | 3 (21.4) | 3 (11.5) | 19 (11.7) | ||
| Total | 62* | 61 | 14 | 26 | 163 | ||
| TNFA 670 | |||||||
| 670 A/A | 52 (82.5) | 54 (88.5) | 11 (78.6) | 19 (73.1) | 136 (82.9) | ||
| 670 A/G | 11 (17.5) | 7 (11.5) | 3 (21.4) | 7 (26.9) | 28 (17.1) | ||
| Total | 63 | 61 | 14 | 26 | 164 | ||
| Haplotypes | |||||||
| 2-2 | 13 (20.6) | 1 (1.6) | 1 (7.1) | 3 (11.5) | 18 (11.0) | ||
| 2-X | 21 (33.3) | 25 (41.0) | 4 (28.6) | 6 (23.1) | 56 (34.1) | ||
| X-X | 29 (46.0) | 35 (57.4) | 9 (64.3) | 17 (65.4) | 90 (54.9) | ||
| Total | 63 | 61 | 14 | 26 | 164 | ||