Table 2. Micro-CT of femurs from... | American Society of Hematology

Table 2.

Micro-CT of femurs from 2-month-old male Csf1^op/Csf1^op; TgSPP/+ and Csf1^op/Csf1^op; TgSGP/+ mice

	wt	*Csf1^op/Csf1^op*	Csf1^op/Csf1^op; TgSGP4/+	Csf1^op/Csf1^op; TgSGP2/+	Csf1^op/Csf1^op; TgSPP7/+	Csf1^op/Csf1^op; TgSPP2/+	Csf1^op/Csf1^op; TgCS5/+
3D-BV/TV, %	0.22 ± 0.02	0.80 ± 0.023^*	0.55 ± 0.01^*	0.24 ± 0.01	0.24 ± 0.026	0.26 ± 0.022^*	0.29 ± 0.052^*
3D-Tb.N, 1/mm	6.6 ± 0.19	13.6 ± 1.78^*	11.8 ± 0.79^*	7.3 ± 0.23^*	6.5 ± 0.24	7.9 ± 0.35^*	7.7 ± 0.5^*
Tb. Th, mm	0.04 ± 0.002	0.11 ± 0.007^*	0.08 ± 0.004^*	0.04 ± 0.002	0.04 ± 0.002	0.04 ± 0.003	0.04 ± 0.005
Tb.Sp, mm	0.16 ± 0.004	0.11 ± 0.05†	0.10 ± 0.013†	0.14 ± 0.005†	0.16 ± 0.007	0.13 ± 0.007†	0.13 ± 0.01†
Imax, mm⁴	0.23 ± 0.011	0.21 ± 0.045	0.29 ± 0.028^*	0.21 ± 0.016	0.25 ± 0.017	0.24 ± 0.018	0.40 ± 0.03^*
Imin, mm⁴	0.12 ± 0.007	0.21 ± 0.05^*	0.14 ± 0.011^*	0.11 ± 0.008†	0.13 ± 0.005	0.11 ± .006†	0.16 ± 0.012^*
Area, mm²	0.85 ± 0.037	0.63 ± 0.049†	0.85 ± 0.09	0.87 ± 0.048	0.85 ± 0.031	0.88 ± 0.028	1.17 ± 0.127^*
Av.Cor.Th., mm	0.22 ± 0.013	0.17 ± 0.01†	0.21 ± 0.012	0.24 ± 0.016	0.21 ± 0.011	0.23 ± 0.01	0.13 ± 0.011†
Width (A/P), mm	1.20 ± 0.026	1.25 ± 0.034‡	1.23 ± 0.029	1.13 ± 0.038†	1.24 ± 0.013	1.15 ± 0.028‡	1.23 ± 0.021
Width (M/L), mm	1.68 ± 0.05	1.74 ± 0.124	1.89 ± 0.045^*	1.67 ± 0.031	1.71 ± 0.024	1.74 ± 0.066	1.91 ± 0.053^*

	wt	*Csf1^op/Csf1^op*	Csf1^op/Csf1^op; TgSGP4/+	Csf1^op/Csf1^op; TgSGP2/+	Csf1^op/Csf1^op; TgSPP7/+	Csf1^op/Csf1^op; TgSPP2/+	Csf1^op/Csf1^op; TgCS5/+
3D-BV/TV, %	0.22 ± 0.02	0.80 ± 0.023^*	0.55 ± 0.01^*	0.24 ± 0.01	0.24 ± 0.026	0.26 ± 0.022^*	0.29 ± 0.052^*
3D-Tb.N, 1/mm	6.6 ± 0.19	13.6 ± 1.78^*	11.8 ± 0.79^*	7.3 ± 0.23^*	6.5 ± 0.24	7.9 ± 0.35^*	7.7 ± 0.5^*
Tb. Th, mm	0.04 ± 0.002	0.11 ± 0.007^*	0.08 ± 0.004^*	0.04 ± 0.002	0.04 ± 0.002	0.04 ± 0.003	0.04 ± 0.005
Tb.Sp, mm	0.16 ± 0.004	0.11 ± 0.05†	0.10 ± 0.013†	0.14 ± 0.005†	0.16 ± 0.007	0.13 ± 0.007†	0.13 ± 0.01†
Imax, mm⁴	0.23 ± 0.011	0.21 ± 0.045	0.29 ± 0.028^*	0.21 ± 0.016	0.25 ± 0.017	0.24 ± 0.018	0.40 ± 0.03^*
Imin, mm⁴	0.12 ± 0.007	0.21 ± 0.05^*	0.14 ± 0.011^*	0.11 ± 0.008†	0.13 ± 0.005	0.11 ± .006†	0.16 ± 0.012^*
Area, mm²	0.85 ± 0.037	0.63 ± 0.049†	0.85 ± 0.09	0.87 ± 0.048	0.85 ± 0.031	0.88 ± 0.028	1.17 ± 0.127^*
Av.Cor.Th., mm	0.22 ± 0.013	0.17 ± 0.01†	0.21 ± 0.012	0.24 ± 0.016	0.21 ± 0.011	0.23 ± 0.01	0.13 ± 0.011†
Width (A/P), mm	1.20 ± 0.026	1.25 ± 0.034‡	1.23 ± 0.029	1.13 ± 0.038†	1.24 ± 0.013	1.15 ± 0.028‡	1.23 ± 0.021
Width (M/L), mm	1.68 ± 0.05	1.74 ± 0.124	1.89 ± 0.045^*	1.67 ± 0.031	1.71 ± 0.024	1.74 ± 0.066	1.91 ± 0.053^*

Data (mean ± SD) from 4 femurs.

3D-BV/TV, % indicates percentage of bone volume to total volume; 3D-Tb.N, 1/mm, number of trabeculae; Tb.Th, mm, trabecular thickness; Tb.Sp, mm, trabecular spacing; A/P indicates anterior/posterior; M/L, medio/lateral; Imax, second moment of area/inertia around A/P axis; Imin, second moment of area/inertia around M/L axis; area, mid-shaft cross-sectional area; and Av.Cor.Th., average cortical thickness.

P < .05; higher than wt.

†

P < .05; lower than wt.

‡

P .08; trend but not significantly different from wt.

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