Table 3. Biomechanical properties of... | American Society of Hematology

Table 3.

Biomechanical properties of femurs of 2-month-old male Csf1^op/Csf1^op; TgSPP/+ and Csf1^op/Csf1^op; TgSGP/+ mice

	wt	*Csf1^op/Csf1^op*	Csf1^op/Csf1^op; TgSGP4/+	Csf1^op/Csf1^op; TgSGP2/+	Csf1^op/Csf1^op; TgSPP7/+	Csf1^op/Csf1^op; TgSPP2/+	Csf1^op/Csf1^op; TgCS5/+
Ultimate load, N	15.2 ± 0.84	17 ± 4.14	26.4 ± 5.49^*	16.3 ± 1.8	15.4 ± 3.5	18.5 ± 2.45^*	26.2 ± 2.07^*
Yield load, N	11.3 ± 3.84	10.9 ± 7.17	20.1 ± 7.54	10.5 ± 4.32	10.5 ± 2.51	13.5 ± 3.5	23.4 ± 1.08^*
Stiffness, N/mm	30.1 ± 5.66	47.9 ± 6.99^*	59.5 ± 11.64^*	29.9 ± 6.63	36.1 ± 8.63	38.3 ± 6.23	64.3 ± 7.06^*
Flexural modulus, N/mm²	2352 ± 433.3	1778 ± 496.2	2714 ± 1239	2764 ± 670.3	2756 ± 659.7	3151 ± 88.5†	3884 ± 411^*
Length, mm	13.8 ± 0.13	11.1 ± 0.32‡	11.71 ± 0.16‡	13.3 ± 0.29‡	13.8 ± 0.15	13.7 ± 0.12	13.5 ± 0.12‡
Ultimate stress, N/mm²	99 ± 3.61	92 ± 26.24	125.8 ± 26.85†	118.8 ± 4.61†	102.0 ± 22.35	125 ± 17.94†	135.9 ± 16.3^*
Yield stress, N/mm²	73.6 ± 21.94	60.2 ± 45.52	97.8 ± 38.2	76.5 ± 32.66	69.8 ± 18.03	98.5 ± 16.9	121.6 ± 14.3†

	wt	*Csf1^op/Csf1^op*	Csf1^op/Csf1^op; TgSGP4/+	Csf1^op/Csf1^op; TgSGP2/+	Csf1^op/Csf1^op; TgSPP7/+	Csf1^op/Csf1^op; TgSPP2/+	Csf1^op/Csf1^op; TgCS5/+
Ultimate load, N	15.2 ± 0.84	17 ± 4.14	26.4 ± 5.49^*	16.3 ± 1.8	15.4 ± 3.5	18.5 ± 2.45^*	26.2 ± 2.07^*
Yield load, N	11.3 ± 3.84	10.9 ± 7.17	20.1 ± 7.54	10.5 ± 4.32	10.5 ± 2.51	13.5 ± 3.5	23.4 ± 1.08^*
Stiffness, N/mm	30.1 ± 5.66	47.9 ± 6.99^*	59.5 ± 11.64^*	29.9 ± 6.63	36.1 ± 8.63	38.3 ± 6.23	64.3 ± 7.06^*
Flexural modulus, N/mm²	2352 ± 433.3	1778 ± 496.2	2714 ± 1239	2764 ± 670.3	2756 ± 659.7	3151 ± 88.5†	3884 ± 411^*
Length, mm	13.8 ± 0.13	11.1 ± 0.32‡	11.71 ± 0.16‡	13.3 ± 0.29‡	13.8 ± 0.15	13.7 ± 0.12	13.5 ± 0.12‡
Ultimate stress, N/mm²	99 ± 3.61	92 ± 26.24	125.8 ± 26.85†	118.8 ± 4.61†	102.0 ± 22.35	125 ± 17.94†	135.9 ± 16.3^*
Yield stress, N/mm²	73.6 ± 21.94	60.2 ± 45.52	97.8 ± 38.2	76.5 ± 32.66	69.8 ± 18.03	98.5 ± 16.9	121.6 ± 14.3†

Data (mean ± SD) were collected from 4 femurs.

N indicates Newton.

P < .05; higher than wt.

P < .09; trend, but not significantly different from wt.

P < .05; lower than wt.