Macrophage densities in the tissues of Csf1op/Csf1op; TgSGP/+ and Csf1op/Csf1op; TgSPP/+ mice
. | Liver cells/mm2 . | . | . | . | . | . | . | |
|---|---|---|---|---|---|---|---|---|
| Genotype . | 2-d-old mouse . | 3-mo-old mouse . | Dermis cells/mm . | Kidney cells/mm2 . | Bladder cells/mm2 . | Tendon cells/mm2 . | MMM cells/mm2 . | |
| wt | 744 ± 71 | 413 ± 10 | 245 ± 12 | 160 ± 17 | 161 ± 29 | + + + + | + + + + | |
| Csf1op/Csf1op | 526 ± 47* | 121 ± 18* | 157 ± 25* | 44 ± 11* | 42 ± 4* | − | − | |
| Csf1op/Csf1op; TgSGP4/+ | 457 ± 31* | 248 ± 5* | 246 ± 27 | 82 ± 9* | 154 ± 20 | + + | + + | |
| Csf1op/Csf1op; TgSGP2/+ | 1251 ± 75† | 464 ± 28 | 326 ± 53† | 198 ± 13 | 184 ± 29 | + + + + | + + + | |
| Csf1op/Csf1op; TgSPP7/+ | 902 ± 79 | 309 ± 38* | 229 ± 16 | 62 ± 14* | 189 ± 23 | + + + | + + | |
| Csf1op/Csf1op; TgSPP2/+ | 1129 ± 72† | 498 ± 75 | 297 ± 11† | 163 ± 20 | 201 ± 19 | + + + + | + + + | |
. | Liver cells/mm2 . | . | . | . | . | . | . | |
|---|---|---|---|---|---|---|---|---|
| Genotype . | 2-d-old mouse . | 3-mo-old mouse . | Dermis cells/mm . | Kidney cells/mm2 . | Bladder cells/mm2 . | Tendon cells/mm2 . | MMM cells/mm2 . | |
| wt | 744 ± 71 | 413 ± 10 | 245 ± 12 | 160 ± 17 | 161 ± 29 | + + + + | + + + + | |
| Csf1op/Csf1op | 526 ± 47* | 121 ± 18* | 157 ± 25* | 44 ± 11* | 42 ± 4* | − | − | |
| Csf1op/Csf1op; TgSGP4/+ | 457 ± 31* | 248 ± 5* | 246 ± 27 | 82 ± 9* | 154 ± 20 | + + | + + | |
| Csf1op/Csf1op; TgSGP2/+ | 1251 ± 75† | 464 ± 28 | 326 ± 53† | 198 ± 13 | 184 ± 29 | + + + + | + + + | |
| Csf1op/Csf1op; TgSPP7/+ | 902 ± 79 | 309 ± 38* | 229 ± 16 | 62 ± 14* | 189 ± 23 | + + + | + + | |
| Csf1op/Csf1op; TgSPP2/+ | 1129 ± 72† | 498 ± 75 | 297 ± 11† | 163 ± 20 | 201 ± 19 | + + + + | + + + | |
Mice used for dermis samples were 2 days old; those for kidney samples, 2 months old; those for bladder samples, 3 months old; tendon, 2 days old; and MMM, 6 weeks old. The antibody for all samples except MMM was F4/80; for MMM, it was MOMA-1.
Data (mean ± SD) are taken from 12 low-power fields of tissues from 2 mice of each genotype. Data are mean ± SD.
MMM indicates marginal metallophyllic macrophages; +, the degree of correction of MMM density in spleen and F4/80+ cell density in tendons of different transgenic lines in comparison with the wt; −, no correction.
P < .05; count lower than wt.
P < .05; count higher than wt.