Concordance and discordance in the 78 MIBS families with respect to inhibitor development
. | No. discordant families with 2 siblings . | . | No. concordant families with 2 siblings . | . | . | . | No. discordant families with more than 2 siblings . | . | . | No. concordant families with more than 2 siblings . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Type of hemophilia A . | HR/No . | LR/No . | HR/HR . | LR/LR . | HR/LR . | No/No . | HR/No/No . | HR/LR/No . | HR/No/No/No . | HR/HR/HR . | LR/LR/LR . | No/No/No . | No. total . | ||||||||
| Severe | 20 | 5 | 11 | 0 | 5 | 15 | 1 | 1 | 0 | 1 | 0 | 1 | 60 | ||||||||
| Moderate | 2 | 2 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 1 | 1 | 12 | ||||||||
| Mild | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 6 | ||||||||
| Total | 23 | 8 | 11 | 1 | 6 | 22 | 1 | 1 | 1 | 1 | 1 | 2 | 78 | ||||||||
. | No. discordant families with 2 siblings . | . | No. concordant families with 2 siblings . | . | . | . | No. discordant families with more than 2 siblings . | . | . | No. concordant families with more than 2 siblings . | . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Type of hemophilia A . | HR/No . | LR/No . | HR/HR . | LR/LR . | HR/LR . | No/No . | HR/No/No . | HR/LR/No . | HR/No/No/No . | HR/HR/HR . | LR/LR/LR . | No/No/No . | No. total . | ||||||||
| Severe | 20 | 5 | 11 | 0 | 5 | 15 | 1 | 1 | 0 | 1 | 0 | 1 | 60 | ||||||||
| Moderate | 2 | 2 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 1 | 1 | 12 | ||||||||
| Mild | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 6 | ||||||||
| Total | 23 | 8 | 11 | 1 | 6 | 22 | 1 | 1 | 1 | 1 | 1 | 2 | 78 | ||||||||
No = no inhibitor history.