Summary of NF-κB requirements in LTβR signaling
. | . | Gene expression . | . | . | In vivo . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Genotype . | NF-κB complexes activated by LTβR . | VCAM ICAM . | Ccl21 . | Cxcl13 . | LN development . | T/B zone . | |||
| WT | p50:RelA, p52:RelB, p50:p50 | +++ | +++ | +++ | +++ | + | |||
| Nfkb1+/–Nfkb2+/– | ND | ND | ND | ND | +++ | + | |||
| Nfkb1–/– | p52:RelA, p52:RelB | + | + | ++ | ++ | + | |||
| Nfkb2–/– | p50:RelA, p50:RelB, p50:p50 | – | + | +/– | ++ | + | |||
| Nfkb1+/–Nfkb2–/– | ND | ND | ND | ND | + | – | |||
| Nfkb1–/–Nfkb2–/– | – | ND | – | – | – | ND | |||
. | . | Gene expression . | . | . | In vivo . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Genotype . | NF-κB complexes activated by LTβR . | VCAM ICAM . | Ccl21 . | Cxcl13 . | LN development . | T/B zone . | |||
| WT | p50:RelA, p52:RelB, p50:p50 | +++ | +++ | +++ | +++ | + | |||
| Nfkb1+/–Nfkb2+/– | ND | ND | ND | ND | +++ | + | |||
| Nfkb1–/– | p52:RelA, p52:RelB | + | + | ++ | ++ | + | |||
| Nfkb2–/– | p50:RelA, p50:RelB, p50:p50 | – | + | +/– | ++ | + | |||
| Nfkb1+/–Nfkb2–/– | ND | ND | ND | ND | + | – | |||
| Nfkb1–/–Nfkb2–/– | – | ND | – | – | – | ND | |||
ND indicates not detected; +++, full response; ++, intermediate response; +, weak response; –, no response; and +/–, very weak response and elevated basal levels.