Incidence rates and standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) of Hodgkin lymphoma, 4 through 27 months after AIDS onset
Category . | No. of cases . | Person-years at risk . | Incidence per 105 py's . | Adjusted RR (95% CI) . | Adjusted P . | Expected cases* . | SIR (95% CI)* . |
|---|---|---|---|---|---|---|---|
| All | 173 | 477 368 | 36.2 | — | 18.2 | 9.4 (8.0-10.9) | |
| Sex | .03 | ||||||
| Male | 154 | 384 990 | 40.0 | 1.86 (1.07-3.23) | 15.6 | 9.7 (8.3-11.4) | |
| Female | 19 | 92 377 | 20.6 | 1.00 | 2.6 | 7.3 (4.4-11.4) | |
| Age at AIDS onset, y | .02 | ||||||
| 15 to less than 30 | 18 | 77 806 | 23.1 | 1.00 | 3.4 | 5.2 (3.1-8.3) | |
| 30 to less than 40 | 73 | 221 611 | 32.9 | 1.38 (0.82-2.32) | 8.6 | 8.3 (6.5-10.4) | |
| 40 to less than 50 | 63 | 131 391 | 47.9 | 1.96 (1.15-3.33) | 4.5 | 13.9 (10.7-17.8) | |
| 50 or more | 19 | 46 558 | 40.8 | 1.64 (0.86-3.16) | 1.7 | 11.4 (6.8-17.7) | |
| Race/ethnicity | .22 | ||||||
| White | 68 | 191 786 | 35.5 | 1.00 | 8.2 | 8.3 (6.5-10.6) | |
| Black | 55 | 175 978 | 31.3 | 1.10 (0.74-1.64) | 5.7 | 9.7 (7.3-12.6) | |
| Hispanic | 48 | 103 262 | 46.5 | 1.50 (1.02-2.22) | 4.4 | 11.0 (8.1-14.6) | |
| Other/unknown | 2 | 6 341 | 31.5 | 0.92 (0.22-3.75) | Excluded | Excluded | |
| Mode of HIV exposure | .09 | ||||||
| MSM | 95 | 214 017 | 44.4 | 1.00 | 8.7 | 10.6 (8.6-13.0) | |
| IDU | 42 | 126 691 | 33.2 | 0.75 (0.50-1.13) | 4.8 | 8.8 (6.4-11.9) | |
| MSM who are also IDU | 5 | 24 982 | 20.0 | 0.45 (0.18-1.12) | 1.0 | 4.9 (1.6-11.3) | |
| Heterosexual | 17 | 54 582 | 31.1 | 0.88 (0.48-1.63) | 1.7 | 9.9 (5.8-15.8) | |
| Other/unknown | 14 | 57 095 | 24.5 | 0.54 (0.30-0.98) | 2.0 | 7.1 (3.9-11.9) | |
| Calendar year of AIDS onset | .01 | ||||||
| 1980-1989 | 24 | 77 602 | 30.9 | 1.00 | 3.4 | 7.0 (4.5-10.4) | |
| 1990-1995 | 77 | 253 604 | 30.4 | 0.96 (0.57-1.61) | 9.5 | 8.1 (6.4-10.1) | |
| 1996-2002 | 72 | 146 162 | 49.3 | 1.60 (0.91-2.82) | 5.3 | 13.2 (10.3-16.7) | |
| CD4 cells/μL | .002† | ||||||
| 0-49 | 17 | 81 977 | 20.7 | 0.46 (0.24-0.86) | 3.0 | 5.3 (3.0-8.6) | |
| 50-99 | 16 | 49 388 | 32.4 | 0.70 (0.37-1.33) | 1.8 | 8.2 (4.6-13.5) | |
| 100-149 | 24 | 53 652 | 44.7 | 0.97 (0.55-1.73) | 2.0 | 12.0 (7.7-17.9) | |
| 150-199 | 41 | 76 306 | 53.7 | 1.18 (0.71-1.97) | 2.8 | 14.5 (10.4-19.6) | |
| 200 or more | 23 | 48 767 | 47.2 | 1.00 | 1.8 | 12.6 (8.0-18.9) | |
| Missing | 52 | 167 277 | 31.1 | 0.79 (0.46-1.35) | 6.7 | 7.8 (5.8-10.2) |
Category . | No. of cases . | Person-years at risk . | Incidence per 105 py's . | Adjusted RR (95% CI) . | Adjusted P . | Expected cases* . | SIR (95% CI)* . |
|---|---|---|---|---|---|---|---|
| All | 173 | 477 368 | 36.2 | — | 18.2 | 9.4 (8.0-10.9) | |
| Sex | .03 | ||||||
| Male | 154 | 384 990 | 40.0 | 1.86 (1.07-3.23) | 15.6 | 9.7 (8.3-11.4) | |
| Female | 19 | 92 377 | 20.6 | 1.00 | 2.6 | 7.3 (4.4-11.4) | |
| Age at AIDS onset, y | .02 | ||||||
| 15 to less than 30 | 18 | 77 806 | 23.1 | 1.00 | 3.4 | 5.2 (3.1-8.3) | |
| 30 to less than 40 | 73 | 221 611 | 32.9 | 1.38 (0.82-2.32) | 8.6 | 8.3 (6.5-10.4) | |
| 40 to less than 50 | 63 | 131 391 | 47.9 | 1.96 (1.15-3.33) | 4.5 | 13.9 (10.7-17.8) | |
| 50 or more | 19 | 46 558 | 40.8 | 1.64 (0.86-3.16) | 1.7 | 11.4 (6.8-17.7) | |
| Race/ethnicity | .22 | ||||||
| White | 68 | 191 786 | 35.5 | 1.00 | 8.2 | 8.3 (6.5-10.6) | |
| Black | 55 | 175 978 | 31.3 | 1.10 (0.74-1.64) | 5.7 | 9.7 (7.3-12.6) | |
| Hispanic | 48 | 103 262 | 46.5 | 1.50 (1.02-2.22) | 4.4 | 11.0 (8.1-14.6) | |
| Other/unknown | 2 | 6 341 | 31.5 | 0.92 (0.22-3.75) | Excluded | Excluded | |
| Mode of HIV exposure | .09 | ||||||
| MSM | 95 | 214 017 | 44.4 | 1.00 | 8.7 | 10.6 (8.6-13.0) | |
| IDU | 42 | 126 691 | 33.2 | 0.75 (0.50-1.13) | 4.8 | 8.8 (6.4-11.9) | |
| MSM who are also IDU | 5 | 24 982 | 20.0 | 0.45 (0.18-1.12) | 1.0 | 4.9 (1.6-11.3) | |
| Heterosexual | 17 | 54 582 | 31.1 | 0.88 (0.48-1.63) | 1.7 | 9.9 (5.8-15.8) | |
| Other/unknown | 14 | 57 095 | 24.5 | 0.54 (0.30-0.98) | 2.0 | 7.1 (3.9-11.9) | |
| Calendar year of AIDS onset | .01 | ||||||
| 1980-1989 | 24 | 77 602 | 30.9 | 1.00 | 3.4 | 7.0 (4.5-10.4) | |
| 1990-1995 | 77 | 253 604 | 30.4 | 0.96 (0.57-1.61) | 9.5 | 8.1 (6.4-10.1) | |
| 1996-2002 | 72 | 146 162 | 49.3 | 1.60 (0.91-2.82) | 5.3 | 13.2 (10.3-16.7) | |
| CD4 cells/μL | .002† | ||||||
| 0-49 | 17 | 81 977 | 20.7 | 0.46 (0.24-0.86) | 3.0 | 5.3 (3.0-8.6) | |
| 50-99 | 16 | 49 388 | 32.4 | 0.70 (0.37-1.33) | 1.8 | 8.2 (4.6-13.5) | |
| 100-149 | 24 | 53 652 | 44.7 | 0.97 (0.55-1.73) | 2.0 | 12.0 (7.7-17.9) | |
| 150-199 | 41 | 76 306 | 53.7 | 1.18 (0.71-1.97) | 2.8 | 14.5 (10.4-19.6) | |
| 200 or more | 23 | 48 767 | 47.2 | 1.00 | 1.8 | 12.6 (8.0-18.9) | |
| Missing | 52 | 167 277 | 31.1 | 0.79 (0.46-1.35) | 6.7 | 7.8 (5.8-10.2) |
Relative risks (RR) for all variables except CD4 count are presented adjusted for cancer registry and all other listed variables except CD4 count. For CD4 count, the adjusted RR is adjusted for cancer registry and all other listed variables. No RR is provided for “All” because there are no strata in this category. Person years do not sum exactly because of rounding. py indicates person years; MSM, men who have sex with men; IDU, intravenous drug users; —, not applicable.
Expected and SIR based on excluding 2 persons with unknown race (N = 171 total).
Test of trend (for CD4 cells/μL, does not include observations with missing CD4 counts).