Clinical parameters of 65 MTS cytotoxicity assay-evaluable patients grouped according to FLT3 mutation status
Characteristic . | FLT3 ITD . | FLT3 TKD-PM . | FLT3 WT . | p* . |
|---|---|---|---|---|
| No. | 21 | 6 | 38 | |
| Sex, no. (%) | 5 (24) | 3 (50) | 18 (47) | .082 |
| Male | 15 (71) | 3 (50) | 19 (50) | |
| Female | 1 (5) | 0 (0) | 1 (3) | |
| Median age, y (range) | 63 (16-87) | 65 (17-74) | 61 (17-87) | .811 |
| Median presenting WBC count, × 109/L (range) | 79.5 (3-230) | 42.4 (29-258) | 25.8 (1-312) | .073 |
| Cytogenetics, no. (%) | ||||
| Favorable | 0 (0) | 1 (17) | 6 (16) | .065 |
| Intermediate | 13 (62) | 4 (67) | 17 (45) | .011 |
| Adverse | 0 (0) | 0 (0) | 4 (11) | .174 |
| Not available | 8 (38) | 1 (17) | 11 (29) | — |
| FAB classification, no. (%) | ||||
| M0 | 0 (0) | 1 (17) | 2 (5) | .315 |
| M1 | 4 (19) | 2 (33) | 8 (21) | .957 |
| M2 | 4 (19) | 0 (0) | 10 (26) | .701 |
| M4 | 7 (33) | 1 (17) | 11 (29) | .488 |
| M5 | 2 (10) | 1 (17) | 3 (8) | .714 |
| RAEB | 0 (0) | 0 (0) | 1 (3) | .482 |
| Not available | 4 (19) | 1 (17) | 3 (8) | — |
Characteristic . | FLT3 ITD . | FLT3 TKD-PM . | FLT3 WT . | p* . |
|---|---|---|---|---|
| No. | 21 | 6 | 38 | |
| Sex, no. (%) | 5 (24) | 3 (50) | 18 (47) | .082 |
| Male | 15 (71) | 3 (50) | 19 (50) | |
| Female | 1 (5) | 0 (0) | 1 (3) | |
| Median age, y (range) | 63 (16-87) | 65 (17-74) | 61 (17-87) | .811 |
| Median presenting WBC count, × 109/L (range) | 79.5 (3-230) | 42.4 (29-258) | 25.8 (1-312) | .073 |
| Cytogenetics, no. (%) | ||||
| Favorable | 0 (0) | 1 (17) | 6 (16) | .065 |
| Intermediate | 13 (62) | 4 (67) | 17 (45) | .011 |
| Adverse | 0 (0) | 0 (0) | 4 (11) | .174 |
| Not available | 8 (38) | 1 (17) | 11 (29) | — |
| FAB classification, no. (%) | ||||
| M0 | 0 (0) | 1 (17) | 2 (5) | .315 |
| M1 | 4 (19) | 2 (33) | 8 (21) | .957 |
| M2 | 4 (19) | 0 (0) | 10 (26) | .701 |
| M4 | 7 (33) | 1 (17) | 11 (29) | .488 |
| M5 | 2 (10) | 1 (17) | 3 (8) | .714 |
| RAEB | 0 (0) | 0 (0) | 1 (3) | .482 |
| Not available | 4 (19) | 1 (17) | 3 (8) | — |
RAEB indicates refractory anemia with excess blasts
P values refer to statistical comparisons made between FLT3/WT and FLT3/ITD groups. Statistical significance of differences in FAB type, cytogenetic risk group, and sex was determined by the χ2 independence test. Statistical significance of differences in age and presenting WBC count was determined by the Student t test