Table 2.

Complete, partial, or no response to fludarabine and ZAP-70 or CD38 expression


Variable

CR, % (95% Cl)

PR, % (95% Cl)

NR, % (95% Cl)
All observations   43   36   14  
ZAP-70*    
    Greater than 20%   31 (13-55)   43 (23-64)   25 (12-44)  
    Lower than 20%   64 (34-82)   33 (14-57)   2 (0.5-8)  
CD38    
    Greater than 30%   19 (6-36)   50 (26-72)   31 (11-53)  
    Lower than 30%
 
61 (35-83)
 
33 (13-51)
 
6 (1-21)
 

Variable

CR, % (95% Cl)

PR, % (95% Cl)

NR, % (95% Cl)
All observations   43   36   14  
ZAP-70*    
    Greater than 20%   31 (13-55)   43 (23-64)   25 (12-44)  
    Lower than 20%   64 (34-82)   33 (14-57)   2 (0.5-8)  
CD38    
    Greater than 30%   19 (6-36)   50 (26-72)   31 (11-53)  
    Lower than 30%
 
61 (35-83)
 
33 (13-51)
 
6 (1-21)
 

For ZAP-70 greater than 20%, n = 104; for ZAP-70 lower than 20%, n = 185.

CR indicates complete remission; PR, partial remission; and NR, no response or progression.

*

P = .003. P values are determined by the proportional odds ordered logistic regression univariate model.

P < .001.

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