Aγ-globin versus Gγ-globin transcription binding sites
Transcription factor . | Position* . | Binding site . |
|---|---|---|
| Aγ-globin promoter | ||
| DTF-1 | – 1480 | gatgttgc |
| NF-ATc | – 1464 | ttttcc |
| Ets-2 | – 1462 | ttcctt |
| RSRFC4 | – 1453 | taatttta |
| EVE | – 1437 | tcattttaat |
| Oct-3 | – 1437 | cattttaat |
| USF | – 1421 | catgtg |
| Elk-1 | – 1412 | gcaggagtg |
| PEA3 | – 1413 | caggatgt |
| INSAF | – 1395 | acatgg |
| E12 | – 1360 | catctg |
| Gγ-globin promoter | ||
| GATA-1 | – 1488 | tgataa |
| NF1 | – 1465 | ctttcc |
| NF-ATp | – 1464 | ctttcct |
| Ets-2 | – 1463 | ttcctt |
| IRF | – 1462 | ctttccttt |
| TBP† | – 1445 | tttaT/Gtt |
| GR | – 1429 | agaaca |
| E2BP | – 1419 | tgcaatat |
| PPAR | – 1396 | aggtca |
| GATA-1 | – 1386 | gtatct |
| Sp1 | – 1365 | ccgcct |
| UME6 | – 1364 | tagccgccta |
Transcription factor . | Position* . | Binding site . |
|---|---|---|
| Aγ-globin promoter | ||
| DTF-1 | – 1480 | gatgttgc |
| NF-ATc | – 1464 | ttttcc |
| Ets-2 | – 1462 | ttcctt |
| RSRFC4 | – 1453 | taatttta |
| EVE | – 1437 | tcattttaat |
| Oct-3 | – 1437 | cattttaat |
| USF | – 1421 | catgtg |
| Elk-1 | – 1412 | gcaggagtg |
| PEA3 | – 1413 | caggatgt |
| INSAF | – 1395 | acatgg |
| E12 | – 1360 | catctg |
| Gγ-globin promoter | ||
| GATA-1 | – 1488 | tgataa |
| NF1 | – 1465 | ctttcc |
| NF-ATp | – 1464 | ctttcct |
| Ets-2 | – 1463 | ttcctt |
| IRF | – 1462 | ctttccttt |
| TBP† | – 1445 | tttaT/Gtt |
| GR | – 1429 | agaaca |
| E2BP | – 1419 | tgcaatat |
| PPAR | – 1396 | aggtca |
| GATA-1 | – 1386 | gtatct |
| Sp1 | – 1365 | ccgcct |
| UME6 | – 1364 | tagccgccta |
Transcription Element Search System (TESS) analysis of the Aγ-globin and Gγ-globin promoters (www.cbil.upenn.edu/cgi-bin/tess/tess). Binding site positions are identified relative to the cap site as recorded in the 81 706-kilobase β-locus sequence (GenBank accession no., gi:28380636, NG_000007).
DTF-1 indicates Drosophila transcription factor-1; NF-ATc, nuclear factor of activated T cells; Ets-related protein; RSRFC4, serum response factor–related protein; EVE, even-skipped; Oct-3, octomer 3; USF, upstream stimulatory factor; PEA3, polyoma virus enhancer A3; INSAF, insulin activator factor; E12, immunoglobulin enhancer binding factor; IRF, interferon-related factor-1; TBP, TATA binding protein; GR, glucocorticoid receptor; E2BP, estrogen binding protein; PPAR, peroxisome proliferators-activated receptor α; UME6, upstream repression sequence 1 binding protein 6
The binding sites shown are from base – 1500 to – 1350 relative to the Aγ-globin and Gγ-globin cap sites
T/G indicates an SNP in the TBP binding site