Table 1.

Deficiency in the Matk/CHK gene impairs the production of IFN-γ upon in vivo antigen challenge


Ovalbumin dose and mice

IFN-γ

IL-2

IL-4

IL-10
100 μg/mL     
    CHK+/+  0.79 ± 0.03   0.44 ± 0.03   0.12 ± 0.01   0.16 ± 0.02  
    CHK-/-  0.24 ± 0.01   0.53 ± 0.02   0.12 ± 0.01   0.15 ± 0.01  
1000 μg/mL     
    CHK+/+  3.27 ± 0.07   0.40 ± 0.01   0.13 ± 0.01   0.16 ± 0.01  
    CHK-/-
 
1.14 ± 0.11
 
0.68 ± 0.01
 
0.12 ± 0.01
 
0.15 ± 0.01
 

Ovalbumin dose and mice

IFN-γ

IL-2

IL-4

IL-10
100 μg/mL     
    CHK+/+  0.79 ± 0.03   0.44 ± 0.03   0.12 ± 0.01   0.16 ± 0.02  
    CHK-/-  0.24 ± 0.01   0.53 ± 0.02   0.12 ± 0.01   0.15 ± 0.01  
1000 μg/mL     
    CHK+/+  3.27 ± 0.07   0.40 ± 0.01   0.13 ± 0.01   0.16 ± 0.01  
    CHK-/-
 
1.14 ± 0.11
 
0.68 ± 0.01
 
0.12 ± 0.01
 
0.15 ± 0.01
 

Numbers denote OD values at 450 nm.

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