Recurrence of CVT and predictors of poor outcome
Study, year . | Predictors of poor outcome . | Recurrent CVT, no./no. total patients (%) . | Other VTE events, no./no. total patients (%) . |
|---|---|---|---|
| Appenzeller et al,28 2005 | Parenchymal involvement: OR, 67.8; CI, 2.12-132.86 (hemorrhagic or ischemic) | 0/24 (0) | 0/24 (0) |
| Thrombophilia or systemic disease: OR, 14.4; CI, 1.35-152.62 | |||
| Stolz et al,9,10 2005 | Age: P < .01 | 2/58 (3.4) | 5/58 (8.6) |
| NIHSS upon admission: P < .01 | |||
| At least 2 seizures during hospital treatment despite antiepileptic treatment: P < .01 | |||
| Venous infarct: P < .01 | |||
| Intracranial hemorrhage: P < .01 | |||
| Ferro et al,1,27 2004 | Older than 37: HR, 2.00; CI, 1.23-3.27 | 14/572 (2.4) | 19/572 (3.3) |
| Male sex: HR, 1.59; CI, 1.01-2.52 | |||
| Any malignancy: HR, 2.90; CI, 1.60-5.08 | |||
| CNS infection: HR, 3.34; CI, 1.98-17.24 | |||
| Any seizure: OR, 6.1; CI, 1.3-16.6 | |||
| Mental status disorder: OR, 3.4; CI, 1.0-11.0 | |||
| GCS less than 9 at admission: OR, 13.1; CI, 3.8-45.4 | |||
| DVS thrombosis: OR, 4.1; CI, 1.1-14.7 | |||
| Lesion posterior fossa: OR, 6.1; CI, 1.1-33.5 | |||
| Worsening of focal sign: OR, 5.3; CI, 1.5-18.9 | |||
| New focal sign: OR, 4.6; CI, 1.2-17.8 | |||
| Breteau et al,21 2003 | Neurologic deficit at time of diagnosis: P = .03 | 0/48 (0) | 3/48 (6.3) |
| Cancer and malignant hemopathy: P = .038 | |||
| Impaired consciousness: NS | |||
| Cerebral hemorrhage: NS | |||
| Baumgartner et al,12 2002 | NA | 0/33 (0) | 0/33 (0) |
| Buccino et al,13 2002 | NA | 1/34 (2.9) | NA |
| Ferro et al,16 2002 | Coma: HR, 1.21; CI, 0.75-1.95 | 2/124 (1.6) | 3/85 (3.5) |
| Worsening after admission: HR, 1.17; CI, 0.85-1.62 | |||
| Aphasia: HR, 1.40; CI, 0.94-2.07 | |||
| Strupp et al,17 2002 | NA | 0/40 (0) | NA |
| de Bruijn et al,19 2001 | Coma: OR, 8.2; CI, 1.3-50.1 | NA | NA |
| Intracranial hemorrhage: OR, 20.7; CI, 1.6-264.3 | |||
| Involvement of straight sinus: NS | |||
| Impaired consciousness: NS | |||
| Mak et al,20 2001 | NA | 0/13 (0) | NA |
| Lleo et al,23 1999 | Impaired consciousness, cancer | NA | NA |
| Preter et al,24 1996 | NA | 9/77 (11.7) | NA |
| Bienfait et al,26 1995 | Coma: RR, 3.5 | NA | NA |
| Hemiparesis at time of diagnosis: RR, 2.3 |
Study, year . | Predictors of poor outcome . | Recurrent CVT, no./no. total patients (%) . | Other VTE events, no./no. total patients (%) . |
|---|---|---|---|
| Appenzeller et al,28 2005 | Parenchymal involvement: OR, 67.8; CI, 2.12-132.86 (hemorrhagic or ischemic) | 0/24 (0) | 0/24 (0) |
| Thrombophilia or systemic disease: OR, 14.4; CI, 1.35-152.62 | |||
| Stolz et al,9,10 2005 | Age: P < .01 | 2/58 (3.4) | 5/58 (8.6) |
| NIHSS upon admission: P < .01 | |||
| At least 2 seizures during hospital treatment despite antiepileptic treatment: P < .01 | |||
| Venous infarct: P < .01 | |||
| Intracranial hemorrhage: P < .01 | |||
| Ferro et al,1,27 2004 | Older than 37: HR, 2.00; CI, 1.23-3.27 | 14/572 (2.4) | 19/572 (3.3) |
| Male sex: HR, 1.59; CI, 1.01-2.52 | |||
| Any malignancy: HR, 2.90; CI, 1.60-5.08 | |||
| CNS infection: HR, 3.34; CI, 1.98-17.24 | |||
| Any seizure: OR, 6.1; CI, 1.3-16.6 | |||
| Mental status disorder: OR, 3.4; CI, 1.0-11.0 | |||
| GCS less than 9 at admission: OR, 13.1; CI, 3.8-45.4 | |||
| DVS thrombosis: OR, 4.1; CI, 1.1-14.7 | |||
| Lesion posterior fossa: OR, 6.1; CI, 1.1-33.5 | |||
| Worsening of focal sign: OR, 5.3; CI, 1.5-18.9 | |||
| New focal sign: OR, 4.6; CI, 1.2-17.8 | |||
| Breteau et al,21 2003 | Neurologic deficit at time of diagnosis: P = .03 | 0/48 (0) | 3/48 (6.3) |
| Cancer and malignant hemopathy: P = .038 | |||
| Impaired consciousness: NS | |||
| Cerebral hemorrhage: NS | |||
| Baumgartner et al,12 2002 | NA | 0/33 (0) | 0/33 (0) |
| Buccino et al,13 2002 | NA | 1/34 (2.9) | NA |
| Ferro et al,16 2002 | Coma: HR, 1.21; CI, 0.75-1.95 | 2/124 (1.6) | 3/85 (3.5) |
| Worsening after admission: HR, 1.17; CI, 0.85-1.62 | |||
| Aphasia: HR, 1.40; CI, 0.94-2.07 | |||
| Strupp et al,17 2002 | NA | 0/40 (0) | NA |
| de Bruijn et al,19 2001 | Coma: OR, 8.2; CI, 1.3-50.1 | NA | NA |
| Intracranial hemorrhage: OR, 20.7; CI, 1.6-264.3 | |||
| Involvement of straight sinus: NS | |||
| Impaired consciousness: NS | |||
| Mak et al,20 2001 | NA | 0/13 (0) | NA |
| Lleo et al,23 1999 | Impaired consciousness, cancer | NA | NA |
| Preter et al,24 1996 | NA | 9/77 (11.7) | NA |
| Bienfait et al,26 1995 | Coma: RR, 3.5 | NA | NA |
| Hemiparesis at time of diagnosis: RR, 2.3 |
VTE indicates venous thromboembolic; NA, not assessed; OR, odds ratio; HR, hazard ratio; NIHSS, National Institutes of Health Stroke Scale; CNS, cerebral nervous system; GCS, Glasgow Coma Scale; DVS, deep vein thrombosis; NS, not significant; and RR, relative risk.