TLR agonists used in this study
Agonist . | TLR . | Derivation . | Source . | Comment . | Reference . |
|---|---|---|---|---|---|
| MALP | TLR2/6 | Mycoplasma fermentans | Alexis Biochemicals | — | Galanos et al33 |
| LPS | TLR4 | Salmonella minnesota R595 (Re) | List Biological Laboratories | Ultrapure | Hoshino et al34 |
| Imiquimod | TLR7 | Imidazoquinoline | Sequoia | Aldara antiviral cream | Hemmi et al24 |
| 3M-013 | TLR7 | Imidazoquinoline | 3M Pharmaceuticals | Novel compound | — |
| 3M-003 | TLR7/8 | Imidazoquinoline | 3M Pharmaceuticals | — | Gorden et al26 |
| R-848 | TLR7/8 | Imidazoquinoline | InvivoGen | Resiquimod | Jurk et al35 |
| 3M-002 | TLR8 | Imidazoquinoline | 3M Pharmaceuticals | — | Gorden et al26 |
| ssRNA polyU | TLR8 | Synthetic polyuridine sequence | InvivoGen | Complexed to cationic lipid to facilitate uptake | Hell et al22 |
| ssRNA40 | TLR8 | Synthetic GU-rich sequence based on U5 region of HIV | InvivoGen | Complexed to cationic lipid to facilitate uptake | Heil et al22 |
Agonist . | TLR . | Derivation . | Source . | Comment . | Reference . |
|---|---|---|---|---|---|
| MALP | TLR2/6 | Mycoplasma fermentans | Alexis Biochemicals | — | Galanos et al33 |
| LPS | TLR4 | Salmonella minnesota R595 (Re) | List Biological Laboratories | Ultrapure | Hoshino et al34 |
| Imiquimod | TLR7 | Imidazoquinoline | Sequoia | Aldara antiviral cream | Hemmi et al24 |
| 3M-013 | TLR7 | Imidazoquinoline | 3M Pharmaceuticals | Novel compound | — |
| 3M-003 | TLR7/8 | Imidazoquinoline | 3M Pharmaceuticals | — | Gorden et al26 |
| R-848 | TLR7/8 | Imidazoquinoline | InvivoGen | Resiquimod | Jurk et al35 |
| 3M-002 | TLR8 | Imidazoquinoline | 3M Pharmaceuticals | — | Gorden et al26 |
| ssRNA polyU | TLR8 | Synthetic polyuridine sequence | InvivoGen | Complexed to cationic lipid to facilitate uptake | Hell et al22 |
| ssRNA40 | TLR8 | Synthetic GU-rich sequence based on U5 region of HIV | InvivoGen | Complexed to cationic lipid to facilitate uptake | Heil et al22 |
— indicates none.