CD38 is a negative prognostic factor in CLL, independently of geographic origin or staining procedures
Geographic area . | No. of patients . | Cutoff system . | Reference . |
|---|---|---|---|
| New York, NY | 47 | % (30) | Damle et al11 |
| Houston, TX | 218 | % (20) | Ibrahim et al13 |
| Reggio Calabria, Italy | 161 | CD38 score | Morabito et al14 |
| Rome, Italy | 168 | % (30) | Del Poeta et al15 |
| San Giovanni Rotondo, Italy | 61 | % (30) | D'Arena et al16 |
| Rochester, MN | 131 | % (30) | Jelinek et al17 |
| Vienna, Austria | 81 | % (30) | Heintel et al18 |
| Essen, Germany | 133 | % (20) | Dürig et al19 |
| Nantes, France | 123 | % (30) | Chevallier et al20 |
| Ulm, Germany | 157 | % (20) | Krober et al21 |
| Barcelona, Spain | 155 | % (20) | Domingo-Domenech et al22 |
| Southampton, United Kingdom | 81 | % (30), ABC | Mainou-Fowler et al23 |
| Cleveland, OH | 131 | %, ABC | Hsi et al24 |
| Liverpool, United Kingdom | 140 | % (20) | Manocha et al25 |
| Cleveland, OH | 24 | % (30) | Chang et al26 |
| Genova, Italy | 52 | % (30) | Ottaggio et al27 |
| Essen, Germany | 79 | % (20) | Dürig et al28 |
| Essen, Germany | 252 | % (30) | Schroers et al29 |
| Roma, Italy | 242 | % (7, 20, 30) | Gentile et al30 |
| Cologne, Germany | 109 | % (30) | Mayr et al31 |
| Rochester, MN | 90 | MFI CD38/MFI control | Pittner et al32 |
| Surrey, United Kingdom | 201 | % (7, 30) | Del Giudice et al33 |
| Aviano, Italy | 137 | % (30) | Zucchetto et al34 |
Geographic area . | No. of patients . | Cutoff system . | Reference . |
|---|---|---|---|
| New York, NY | 47 | % (30) | Damle et al11 |
| Houston, TX | 218 | % (20) | Ibrahim et al13 |
| Reggio Calabria, Italy | 161 | CD38 score | Morabito et al14 |
| Rome, Italy | 168 | % (30) | Del Poeta et al15 |
| San Giovanni Rotondo, Italy | 61 | % (30) | D'Arena et al16 |
| Rochester, MN | 131 | % (30) | Jelinek et al17 |
| Vienna, Austria | 81 | % (30) | Heintel et al18 |
| Essen, Germany | 133 | % (20) | Dürig et al19 |
| Nantes, France | 123 | % (30) | Chevallier et al20 |
| Ulm, Germany | 157 | % (20) | Krober et al21 |
| Barcelona, Spain | 155 | % (20) | Domingo-Domenech et al22 |
| Southampton, United Kingdom | 81 | % (30), ABC | Mainou-Fowler et al23 |
| Cleveland, OH | 131 | %, ABC | Hsi et al24 |
| Liverpool, United Kingdom | 140 | % (20) | Manocha et al25 |
| Cleveland, OH | 24 | % (30) | Chang et al26 |
| Genova, Italy | 52 | % (30) | Ottaggio et al27 |
| Essen, Germany | 79 | % (20) | Dürig et al28 |
| Essen, Germany | 252 | % (30) | Schroers et al29 |
| Roma, Italy | 242 | % (7, 20, 30) | Gentile et al30 |
| Cologne, Germany | 109 | % (30) | Mayr et al31 |
| Rochester, MN | 90 | MFI CD38/MFI control | Pittner et al32 |
| Surrey, United Kingdom | 201 | % (7, 30) | Del Giudice et al33 |
| Aviano, Italy | 137 | % (30) | Zucchetto et al34 |
ABC indicates antibody binding capacity; and MFI, mean fluorescence intensity.