Main functional features of human CD38 in distinct cell lineages and populations
Cell lineage . | Associated molecules . | Signaling pathway . | Functions . |
|---|---|---|---|
| Thymocytes | CD3ϵ | Unknown | Control of apoptosis |
| Circulating T cells | CD3/TCR complex | ZAP-70, PLC-γ1, ERK1/2 | Activation, proliferation, cytokine release |
| Residential T cells | Unknown (CD2?) | ERK1/2 | Activation, cytokine release |
| Circulating NK cells | CD16 | CD3ζ, ZAP-70, Cbl, ERK1/2 | Regulation of cytotoxicity |
| LAK cells | Unknown | Unknown | Cytokine release, IL-8—mediated migration |
| Monocytes | MHC class II, CD9 | c-cbl, Fgr, Hck | Modulation of superantigen presentation; cytokine release; chemotaxis to CXCR4, CCR1, and CCR5 ligands |
| Dendritic cells | CCR7, CD83, CD11b | Unknown | Maturation, IL-12 induction, chemotaxis, and transendothelial migration to CCL21 |
| Immature B cells | CD19 | c-cbl, PLC-γ2, PI-3K, ERK1/2 | Apoptosis |
| Mature B cells | sIgM, BCR complex | Bcl-2 upregulation | Rescue from apoptosis |
Cell lineage . | Associated molecules . | Signaling pathway . | Functions . |
|---|---|---|---|
| Thymocytes | CD3ϵ | Unknown | Control of apoptosis |
| Circulating T cells | CD3/TCR complex | ZAP-70, PLC-γ1, ERK1/2 | Activation, proliferation, cytokine release |
| Residential T cells | Unknown (CD2?) | ERK1/2 | Activation, cytokine release |
| Circulating NK cells | CD16 | CD3ζ, ZAP-70, Cbl, ERK1/2 | Regulation of cytotoxicity |
| LAK cells | Unknown | Unknown | Cytokine release, IL-8—mediated migration |
| Monocytes | MHC class II, CD9 | c-cbl, Fgr, Hck | Modulation of superantigen presentation; cytokine release; chemotaxis to CXCR4, CCR1, and CCR5 ligands |
| Dendritic cells | CCR7, CD83, CD11b | Unknown | Maturation, IL-12 induction, chemotaxis, and transendothelial migration to CCL21 |
| Immature B cells | CD19 | c-cbl, PLC-γ2, PI-3K, ERK1/2 | Apoptosis |
| Mature B cells | sIgM, BCR complex | Bcl-2 upregulation | Rescue from apoptosis |
LAK indicates lymphokine-activated killer.