Notch activation up-regulates the expression of Runx1
. | RAU . | Mean . | Notch-mock . |
|---|---|---|---|
| Experiment 1 | 2.78* | ||
| NIH3T3-Mock | 0.112634; 0.077514; 0.093663 | 0.094604 | |
| NIH3T3-Notch | 0.263982; 0.241864; 0.282636 | 0.262827 | |
| Experiment 2 | 4.12* | ||
| NIH3T3-Mock | 0.038500; 0.045755; 0.044123 | 0.042792 | |
| NIH3T3-Notch | 0.186016; 0.148638; 0.194443 | 0.176366 |
. | RAU . | Mean . | Notch-mock . |
|---|---|---|---|
| Experiment 1 | 2.78* | ||
| NIH3T3-Mock | 0.112634; 0.077514; 0.093663 | 0.094604 | |
| NIH3T3-Notch | 0.263982; 0.241864; 0.282636 | 0.262827 | |
| Experiment 2 | 4.12* | ||
| NIH3T3-Mock | 0.038500; 0.045755; 0.044123 | 0.042792 | |
| NIH3T3-Notch | 0.186016; 0.148638; 0.194443 | 0.176366 |
Data are from 2 independent experiments in triplicate. RAU, relative arbitrary units; Notch-mock, the ratio of RAU by constitutive active Notch 1 infection and RAU by mock infection.
P < .01 (2-tailed, unequal variance t test).