Multivariate analysis of 36-month nonrelapse mortality in a Cox model
Variable . | No. evaluable . | Hazard ratio on NRM (95% CI)* . | P (overall) contrast† . |
|---|---|---|---|
| Transplantation group | |||
| Standard myeloablative conditioning‡ | 621 | (1) | |
| Reduced-intensity conditioning | 215 | 0.61 (0.41-0.91) | .015 |
| Patient age | |||
| 50 y or younger‡ | 508 | (1) | |
| Older than 50 y | 326 | 1.4 (1.1-1.8) | .04 |
| Response to AML-type chemotherapy | (.025) | ||
| First complete remission‡ | 276 | (1) | |
| Untreated | 235 | 1.5 (1.04-2.1) | .03 |
| Treated, but not in CR1 | 241 | 1.6 (1.1-2.2) | .01 |
| CD34+ cell dose infused§ | (.1) | ||
| Low‡ | 247 | (1) | |
| High | 278 | 0.7 (0.5-0.98) | .04 |
| Interval from diagnosis to transplantation | |||
| 3 to 6 mo‡ | 192 | (1) | |
| Other than 3 to 6 mo∥ | 429 | 1.4 (1.03-1.9) | .03 |
Variable . | No. evaluable . | Hazard ratio on NRM (95% CI)* . | P (overall) contrast† . |
|---|---|---|---|
| Transplantation group | |||
| Standard myeloablative conditioning‡ | 621 | (1) | |
| Reduced-intensity conditioning | 215 | 0.61 (0.41-0.91) | .015 |
| Patient age | |||
| 50 y or younger‡ | 508 | (1) | |
| Older than 50 y | 326 | 1.4 (1.1-1.8) | .04 |
| Response to AML-type chemotherapy | (.025) | ||
| First complete remission‡ | 276 | (1) | |
| Untreated | 235 | 1.5 (1.04-2.1) | .03 |
| Treated, but not in CR1 | 241 | 1.6 (1.1-2.2) | .01 |
| CD34+ cell dose infused§ | (.1) | ||
| Low‡ | 247 | (1) | |
| High | 278 | 0.7 (0.5-0.98) | .04 |
| Interval from diagnosis to transplantation | |||
| 3 to 6 mo‡ | 192 | (1) | |
| Other than 3 to 6 mo∥ | 429 | 1.4 (1.03-1.9) | .03 |
Other variables with nonsignificant trends toward increasing NRM (P value, .06-0.1): (1) Bone marrow as stem cell source (P = .08).
A hazard ratio less than 1.0 indicates that the variable leads to a reduction of NRM, while a value above 1.0 indicates that it leads to an increase in NRM.
Some risk factors in the Cox model contain a category for “unknown” to avoid loss of information; the overall P value between brackets denotes the P value of the complete risk factor; the individual P values denote the P values of the given contrasts to the reference category. For clarity, the “unknown” categories as well as the nonsignificant risk factors have been omitted from the table.
Reference group.
See Table 1 for details.
P = .1