Clinical and immunologic characteristics of 157 children with T-ALL according to either the presence or the absence of NOTCH1 mutations
. | NOTCH1 mutation . | . | . | |
|---|---|---|---|---|
| Characteristic . | Positive, no. (%) . | Negative, no. (%) . | P* . | |
| Sex | .29 | |||
| Male | 64 (78.0) | 53 (70.7) | ||
| Female | 18 (22.0) | 22 (29.3) | ||
| Age at diagnosis | .44 | |||
| Younger than 10 y | 52 (63.4) | 43 (57.3) | ||
| 10 y or older | 30 (36.6) | 32 (42.7) | ||
| Presenting WBC count at diagnosis | .90 | |||
| Less than 10 × 109/L | 10 (12.2) | 9 (12.0) | ||
| 10 × 109/L to less than 50 × 109/L | 22 (30.5) | 23 (30.7) | ||
| 50 × 109/L to less than 100 × 109/L | 19 (23.2) | 14 (18.7) | ||
| 100 × 109/L or more | 28 (34.1) | 29 (38.7) | ||
| T-cell immunophenotype† | .019 | |||
| Pro | 2 (2.4) | 2 (2.7) | ||
| Pre | 10 (12.2) | 12 (16.0) | ||
| Cortical | 65 (79.3) | 43 (57.3) | ||
| Mature | 4 (4.9) | 14 (18.7) | ||
| T not further classified | 1 (1.2) | 4 (5.3) | ||
. | NOTCH1 mutation . | . | . | |
|---|---|---|---|---|
| Characteristic . | Positive, no. (%) . | Negative, no. (%) . | P* . | |
| Sex | .29 | |||
| Male | 64 (78.0) | 53 (70.7) | ||
| Female | 18 (22.0) | 22 (29.3) | ||
| Age at diagnosis | .44 | |||
| Younger than 10 y | 52 (63.4) | 43 (57.3) | ||
| 10 y or older | 30 (36.6) | 32 (42.7) | ||
| Presenting WBC count at diagnosis | .90 | |||
| Less than 10 × 109/L | 10 (12.2) | 9 (12.0) | ||
| 10 × 109/L to less than 50 × 109/L | 22 (30.5) | 23 (30.7) | ||
| 50 × 109/L to less than 100 × 109/L | 19 (23.2) | 14 (18.7) | ||
| 100 × 109/L or more | 28 (34.1) | 29 (38.7) | ||
| T-cell immunophenotype† | .019 | |||
| Pro | 2 (2.4) | 2 (2.7) | ||
| Pre | 10 (12.2) | 12 (16.0) | ||
| Cortical | 65 (79.3) | 43 (57.3) | ||
| Mature | 4 (4.9) | 14 (18.7) | ||
| T not further classified | 1 (1.2) | 4 (5.3) | ||