Table 1. Kinetic constants for pro-uPA... | American Society of Hematology

Table 1.

Kinetic constants for pro-uPA activation

suPAR	k_cat, s^-1	K_m, μM	K_cat/K_m, M^-1s^-1
Plasmin
Without	12.8 ± 1.3	1.06 ± 0.17	1.21 × 10⁷
With	6.82 ± 2.23	0.79 ± 0.37	8.63 × 10⁶
Matriptase
Without	0.466 ± 0.016	4.01 ± 0.17	1.16 × 10⁵
With	0.129 ± 0.010	1.24 ± 0.15	1.04 × 10⁵

suPAR	k_cat, s^-1	K_m, μM	K_cat/K_m, M^-1s^-1
Plasmin
Without	12.8 ± 1.3	1.06 ± 0.17	1.21 × 10⁷
With	6.82 ± 2.23	0.79 ± 0.37	8.63 × 10⁶
Matriptase
Without	0.466 ± 0.016	4.01 ± 0.17	1.16 × 10⁵
With	0.129 ± 0.010	1.24 ± 0.15	1.04 × 10⁵

Data are shown for the activation of pro-uPA by plasmin and matriptase, both in the presence and absence of equimolar amounts of soluble uPAR. Values for k_cat and K_m are shown as mean ± standard error of the parameter estimated by nonlinear regression

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