Half-lives of VWF, FVIII, and VWFpp in affected family members after administration of DDAVP or Humate-P
Family member . | t1/2 (VWF) after DDAVP, h . | t1/2 (FVIII) after DDAVP, h . | t1/2 (VWFpp) after DDAVP, h . | t1/2 (VWF) after Humate-P, h . |
|---|---|---|---|---|
| A-I-1 | 1.0 | 1.3 | 2.5 | 12.7 |
| A-II-2 | 1.2 | 1.9 | ND | ND |
| A-III-1 | 3.1 | 2.3 | 2.4 | ND |
| B-I1 | 1.4 | 1.6 | ND | 11.8 |
| B-II1 | 1.7 | ND | ND | ND |
| C-II-3 | 1.4 | 1.3 | ND | 9.9 |
| C-III-3 | 3.6 | ND | ND | ND |
| Type 1-1 | 9.2 | ND | ND | ND |
| Type 1-2 | 11.0 | ND | ND | ND |
| Type 1-3 | 12.5 | ND | ND | ND |
| Healthy individuals,13,14,32 range | 8-12 | 11-18 | 2-3 | 8-12 |
Family member . | t1/2 (VWF) after DDAVP, h . | t1/2 (FVIII) after DDAVP, h . | t1/2 (VWFpp) after DDAVP, h . | t1/2 (VWF) after Humate-P, h . |
|---|---|---|---|---|
| A-I-1 | 1.0 | 1.3 | 2.5 | 12.7 |
| A-II-2 | 1.2 | 1.9 | ND | ND |
| A-III-1 | 3.1 | 2.3 | 2.4 | ND |
| B-I1 | 1.4 | 1.6 | ND | 11.8 |
| B-II1 | 1.7 | ND | ND | ND |
| C-II-3 | 1.4 | 1.3 | ND | 9.9 |
| C-III-3 | 3.6 | ND | ND | ND |
| Type 1-1 | 9.2 | ND | ND | ND |
| Type 1-2 | 11.0 | ND | ND | ND |
| Type 1-3 | 12.5 | ND | ND | ND |
| Healthy individuals,13,14,32 range | 8-12 | 11-18 | 2-3 | 8-12 |
Multimers were normal in all family members and healthy individuals.
ND indicates not done.