Characteristics of the clinical study population
Characteristic . | Group 1 . | Group 2 . | Group 3 . | Group 4 . |
|---|---|---|---|---|
| No. of patients | 29 | 24 | 37 | 30 |
| Mean age, y (SD) | 2.8 (2.6) | 2.7 (2.1) | 2.7 (1.8) | 3.8 (2.1) |
| Male-female ratio | 0.8 | 1.8 | 1.0 | 0.6 |
| Mean weight-for-age Z-score (SD) | –2.4 (1.2) | –1.7 (1.6) | –1.7 (1.0) | –1.1 (1.7) |
| Mean Hb level, g/L (SD) | 40 (6) | 60 (4) | 82 (8) | 110 (7) |
| Mean HCT (SD) | .129 (.02) | .195 (.015) | .261 (.024) | .340 (.024) |
| Mean MCV, fL (SD) | 67.5 (8.1) | 69.1 (8.9) | 66.6 (7.6) | 73.5 (6.9) |
| Mean MCH, pg (SD) | 21.4 (3.6) | 21.4 (3.2) | 21.0 (2.9) | 23.8 (2.4) |
| Median reticulocyte count on admission, × 109/L (IQR) | 47.2 (24.8-58.7) | 56.2 (18.4-106.3) | 42.4 (20.2-62.5) | 23.8 (15.4-34.7) |
| Median reticulocyte count at 1 week, × 109/L (IQR) | 216.4 (129.3-358.6) | 294.0 (125.1-365.8) | 153.6 (111.0-218.5) | 55.8 (39.3-84.8) |
| Median P falciparum count, × 103/μL (IQR) | 25.5 (0.6-119) | 10.6 (4.2-96.3) | 14.2 (3.2-147) | 10.3 (2.1-28.2) |
| Median erythropoietin level, mU/mL (IQR) | 5033 (3117-5955) | 1473 (343.5-3114) | 152 (67-252) | 40.4 (5.3-74.3) |
| Coombs test positive, % | 34.5 | 41.7 | 37.8 | 26.7 |
Characteristic . | Group 1 . | Group 2 . | Group 3 . | Group 4 . |
|---|---|---|---|---|
| No. of patients | 29 | 24 | 37 | 30 |
| Mean age, y (SD) | 2.8 (2.6) | 2.7 (2.1) | 2.7 (1.8) | 3.8 (2.1) |
| Male-female ratio | 0.8 | 1.8 | 1.0 | 0.6 |
| Mean weight-for-age Z-score (SD) | –2.4 (1.2) | –1.7 (1.6) | –1.7 (1.0) | –1.1 (1.7) |
| Mean Hb level, g/L (SD) | 40 (6) | 60 (4) | 82 (8) | 110 (7) |
| Mean HCT (SD) | .129 (.02) | .195 (.015) | .261 (.024) | .340 (.024) |
| Mean MCV, fL (SD) | 67.5 (8.1) | 69.1 (8.9) | 66.6 (7.6) | 73.5 (6.9) |
| Mean MCH, pg (SD) | 21.4 (3.6) | 21.4 (3.2) | 21.0 (2.9) | 23.8 (2.4) |
| Median reticulocyte count on admission, × 109/L (IQR) | 47.2 (24.8-58.7) | 56.2 (18.4-106.3) | 42.4 (20.2-62.5) | 23.8 (15.4-34.7) |
| Median reticulocyte count at 1 week, × 109/L (IQR) | 216.4 (129.3-358.6) | 294.0 (125.1-365.8) | 153.6 (111.0-218.5) | 55.8 (39.3-84.8) |
| Median P falciparum count, × 103/μL (IQR) | 25.5 (0.6-119) | 10.6 (4.2-96.3) | 14.2 (3.2-147) | 10.3 (2.1-28.2) |
| Median erythropoietin level, mU/mL (IQR) | 5033 (3117-5955) | 1473 (343.5-3114) | 152 (67-252) | 40.4 (5.3-74.3) |
| Coombs test positive, % | 34.5 | 41.7 | 37.8 | 26.7 |
Children were recruited into each group based on the Hb level in the screening test, namely group 1 (Hb, < 50 g/L [5.0 g/dL]), group 2 (Hb, 50-69 g/L [5.0-6.9 g/dL]), group 3 (Hb, 70-99 g/L [7.0-9.9 g/dL]), and group 4 (Hb, 100 g/L [10.0 g/dL] or greater). In the final analysis, the group sizes differed slightly as the measurement of hemoglobin in the outpatient department, where most patients were recruited, differed from the measurement of hemoglobin by the regularly calibrated Coulter counter