Tumor angiogenesis genes
. | . | . | . | . | . | . | Library origin§ . | . | . | |
|---|---|---|---|---|---|---|---|---|---|---|
| TAG . | Gene ID* . | . | GenBank accession no. . | Function† . | Component‡ . | No. spots representing TAG . | HUVEC . | TEC . | CGH∥ . | |
| Previously associated with angiogenesis | ||||||||||
| TAG-5 | Collagen type I, α1 | COL1A1 | NM_000088.2 | Extracellular matrix | E | 4 | — | × | — | |
| TAG-7 | Collagen type IV, α1 | COL4A1 | NM_001845.2 | Extracellular matrix | E | 16 | × | × | G13q34 | |
| TAG-21 | High-mobility group protein-1 | HMGB1 | NM_002128.3 | Transcription | N, E | 1 | — | × | G13q12 | |
| TAG-25 | Hairy/enhancer of split with YRPW motif | HEYL | NM_014571 | Transcription | N | 1 | — | × | — | |
| TAG-29 | Insulin-like growth factor-binding protein 7 | IGFBP7 | NM_001553 | Extracellular matrix | E | 1 | × | — | — | |
| TAG-31 | Phosphatidic acid phosphatase type 2B | PPAP2B | CV337080 | Cell surface | P | 1 | — | × | — | |
| TAG-33 | Secreted protein acidic, rich in cysteine | SPARC | NM_003118.1 | Extracellular matrix | E | 5 | — | × | — | |
| No previous association with angiogenesis | ||||||||||
| TAG-1 | Actin-related protein 2/3 complex | ARPC2 | NM_152862.1 | Cytoskeleton organization | C | 2 | — | × | — | |
| TAG-3 | CD59 antigen p18-20 | CD59 | NM_000611 | Cell surface | P | 1 | — | × | — | |
| TAG-4 | CDK2-associated protein 1 | CDK2AP1 | NM_004642.2 | Cell growth | C, N | 1 | — | × | — | |
| TAG-23 | IMAGE 5299642 | EST | BC041913 | Unknown | Unknown | 1 | × | — | — | |
| TAG-27 | IMAGE 4332094 | EST | NM_017994.1 | Unknown | Unknown | 1 | — | × | G7q11.21 | |
| TAG-28 | Insulin receptor precursor | HSIRPR | X02160 | Cell surface | P | 1 | — | × | — | |
| TAG-30 | Lactate dehydrogenase B | LDHB | NM_002300 | Cellular metabolism | C | 1 | × | — | — | |
| TAG-32 | Polyhomeotic-like 3 | PHC3 | AJ320486 | Unknown | N | 1 | — | × | — | |
| TAG-38 | Voltage-gated K channel β-subunit 4.1 | HSPC014 | AF077200 | Unknown | Unknown | 1 | × | — | G13q12.3 | |
| TAG-39 | Vimentin | VIM | X56134 | Cytoskeleton organization | C | 3 | × | × | — | |
. | . | . | . | . | . | . | Library origin§ . | . | . | |
|---|---|---|---|---|---|---|---|---|---|---|
| TAG . | Gene ID* . | . | GenBank accession no. . | Function† . | Component‡ . | No. spots representing TAG . | HUVEC . | TEC . | CGH∥ . | |
| Previously associated with angiogenesis | ||||||||||
| TAG-5 | Collagen type I, α1 | COL1A1 | NM_000088.2 | Extracellular matrix | E | 4 | — | × | — | |
| TAG-7 | Collagen type IV, α1 | COL4A1 | NM_001845.2 | Extracellular matrix | E | 16 | × | × | G13q34 | |
| TAG-21 | High-mobility group protein-1 | HMGB1 | NM_002128.3 | Transcription | N, E | 1 | — | × | G13q12 | |
| TAG-25 | Hairy/enhancer of split with YRPW motif | HEYL | NM_014571 | Transcription | N | 1 | — | × | — | |
| TAG-29 | Insulin-like growth factor-binding protein 7 | IGFBP7 | NM_001553 | Extracellular matrix | E | 1 | × | — | — | |
| TAG-31 | Phosphatidic acid phosphatase type 2B | PPAP2B | CV337080 | Cell surface | P | 1 | — | × | — | |
| TAG-33 | Secreted protein acidic, rich in cysteine | SPARC | NM_003118.1 | Extracellular matrix | E | 5 | — | × | — | |
| No previous association with angiogenesis | ||||||||||
| TAG-1 | Actin-related protein 2/3 complex | ARPC2 | NM_152862.1 | Cytoskeleton organization | C | 2 | — | × | — | |
| TAG-3 | CD59 antigen p18-20 | CD59 | NM_000611 | Cell surface | P | 1 | — | × | — | |
| TAG-4 | CDK2-associated protein 1 | CDK2AP1 | NM_004642.2 | Cell growth | C, N | 1 | — | × | — | |
| TAG-23 | IMAGE 5299642 | EST | BC041913 | Unknown | Unknown | 1 | × | — | — | |
| TAG-27 | IMAGE 4332094 | EST | NM_017994.1 | Unknown | Unknown | 1 | — | × | G7q11.21 | |
| TAG-28 | Insulin receptor precursor | HSIRPR | X02160 | Cell surface | P | 1 | — | × | — | |
| TAG-30 | Lactate dehydrogenase B | LDHB | NM_002300 | Cellular metabolism | C | 1 | × | — | — | |
| TAG-32 | Polyhomeotic-like 3 | PHC3 | AJ320486 | Unknown | N | 1 | — | × | — | |
| TAG-38 | Voltage-gated K channel β-subunit 4.1 | HSPC014 | AF077200 | Unknown | Unknown | 1 | × | — | G13q12.3 | |
| TAG-39 | Vimentin | VIM | X56134 | Cytoskeleton organization | C | 3 | × | × | — | |
Extracellular matrix indicates ECM organization and biosynthesis; cell surface, cell-surface receptor-linked signal transduction, antigen presentation; transcription, regulation of transcription; cytoskeleton organization, cytoskeleton organization and biogenesis; cell growth, regulation of cell growth, cell cycle, apoptosis; protein regulation, cellular protein metabolism, protein biosynthesis, translation, transport; C, cytoplasm; N, nucleus; P, plasma membrane; E, extracellular; CGH, comparative genomic hybridization; and —, not applicable.
Sequence identity.
Functional classification of the reported TAG, inferred from Gene Ontology Database.
Cellular component of the reported TAG, inferred from Gene Ontology Database.
SSH cDNA repertoire origin of the spots.
Progenetix large intestine database (www.progenetix.de). G indicates gain; L, loss; defined by 15% difference in aberrations per band.