Clinical events in children with sickle cell anemia with and without asthma
. | Asthma . | No asthma . | P . |
|---|---|---|---|
| No. patients | 49 | 242 | |
| Acute chest syndrome (ACS), events per patient year | 0.39 | 0.20 | < .001* |
| Median time to first ACS, y | 2.4 | 4.6 | .01† |
| Pain, no. events per patient year | 1.39 | 0.47 | < .001‡ |
| Transfusion, no. events per patient year | 1.00 | 0.60 | .02 |
. | Asthma . | No asthma . | P . |
|---|---|---|---|
| No. patients | 49 | 242 | |
| Acute chest syndrome (ACS), events per patient year | 0.39 | 0.20 | < .001* |
| Median time to first ACS, y | 2.4 | 4.6 | .01† |
| Pain, no. events per patient year | 1.39 | 0.47 | < .001‡ |
| Transfusion, no. events per patient year | 1.00 | 0.60 | .02 |
Incidence rates compared by negative binomial regression controlling for age at time of asthma diagnosis and lifetime average hemoglobin concentration, white blood cell count, and percent fetal hemoglobin.
Median time to first event estimated by Kaplan-Meier, P value from Cox regression controlling for age at time of asthma diagnosis and lifetime average hemoglobin concentration, white blood cell count, and percent fetal hemoglobin.
Incidence rates compared by negative binomial regression controlling for age at time of asthma diagnosis, sex, and lifetime average hematocrit and percent fetal hemoglobin.