Comparison of dGTP accumulation either with forodesine, dGuo, or both
Paramater . | Untreated, 8 h . | Forodesine, 8 h . | dGuo, 8 h . | Forodesine + dGuo, 8 h . |
|---|---|---|---|---|
| Patient no. 1 | ||||
| dGTP, μM | 6.0 | 7.6 | 8.2 | 29.6 |
| Caspase 3, % activation | 74 | 93 | 50 | 122 |
| Patient no. 2 | ||||
| dGTP, μM | 7.1 | 5.0 | 17.0 | 18.7 |
| Caspase 3, % activation | 1616 | 1578 | 1999 | 1962 |
| Patient no. 3 | ||||
| dGTP, μM | 6.0 | 6.1 | 51.7 | 54.4 |
| Caspase 3, % activation | 111 | 98 | 140 | 135 |
Paramater . | Untreated, 8 h . | Forodesine, 8 h . | dGuo, 8 h . | Forodesine + dGuo, 8 h . |
|---|---|---|---|---|
| Patient no. 1 | ||||
| dGTP, μM | 6.0 | 7.6 | 8.2 | 29.6 |
| Caspase 3, % activation | 74 | 93 | 50 | 122 |
| Patient no. 2 | ||||
| dGTP, μM | 7.1 | 5.0 | 17.0 | 18.7 |
| Caspase 3, % activation | 1616 | 1578 | 1999 | 1962 |
| Patient no. 3 | ||||
| dGTP, μM | 6.0 | 6.1 | 51.7 | 54.4 |
| Caspase 3, % activation | 111 | 98 | 140 | 135 |