Frequency of KIT mutation in different diagnostic subgroups of adult patients with systemic mastocytosis
. | . | Patients with KIT mutation on BM mast cells, no. (%) . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Category . | Patient mast cells, no. of total (%) . | Mast cells . | CD34+ HPCs . | Eosinophils . | Monocytes . | Neutrophils . | Lymphocytes . | |||||
| MCL* | 5/6 (83) | 2/2 (100) | 2/2 (100) | 1/1 (100) | NA | 1/1 (100) | NA | |||||
| ISM | 72/74 (97)§ | 43/43 (100) | 9/38 (24) | 9/42 (21) | 4/37 (11) | 3/37 (8) | 1/10 (10) | |||||
| SM-ana† | 7/7 (100)∥ | 6/6 (100) | 0/6 (0) | 0/6 (0) | 0/6 (0) | 0/6 (0) | 0/2 (0) | |||||
| WDSM‡ | 2/7 (29) | 2/2 (100) | 1/2 (50) | 0/2 (0) | 0/2 (0) | 0/2 (0) | 0/2 (0) | |||||
| ASM | 6/6§ (100) | 5/5 (100) | 3/4 (75) | 4/5 (80) | 3/4 (75) | 4/5 (80) | 3/4 (75) | |||||
| SM-AHNMD | 13/13 (100)¶ | 9/9 (100) | 6/9 (67) | 6/9 (67) | 5/8 (63) | 4/7 (57) | 2/5 (40) | |||||
| Total | 105/113 (93) | 67/67 (100) | 21/61 (34) | 20/65 (31) | 12/57 (21) | 12/58 (21) | 6/23 (26) | |||||
. | . | Patients with KIT mutation on BM mast cells, no. (%) . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Category . | Patient mast cells, no. of total (%) . | Mast cells . | CD34+ HPCs . | Eosinophils . | Monocytes . | Neutrophils . | Lymphocytes . | |||||
| MCL* | 5/6 (83) | 2/2 (100) | 2/2 (100) | 1/1 (100) | NA | 1/1 (100) | NA | |||||
| ISM | 72/74 (97)§ | 43/43 (100) | 9/38 (24) | 9/42 (21) | 4/37 (11) | 3/37 (8) | 1/10 (10) | |||||
| SM-ana† | 7/7 (100)∥ | 6/6 (100) | 0/6 (0) | 0/6 (0) | 0/6 (0) | 0/6 (0) | 0/2 (0) | |||||
| WDSM‡ | 2/7 (29) | 2/2 (100) | 1/2 (50) | 0/2 (0) | 0/2 (0) | 0/2 (0) | 0/2 (0) | |||||
| ASM | 6/6§ (100) | 5/5 (100) | 3/4 (75) | 4/5 (80) | 3/4 (75) | 4/5 (80) | 3/4 (75) | |||||
| SM-AHNMD | 13/13 (100)¶ | 9/9 (100) | 6/9 (67) | 6/9 (67) | 5/8 (63) | 4/7 (57) | 2/5 (40) | |||||
| Total | 105/113 (93) | 67/67 (100) | 21/61 (34) | 20/65 (31) | 12/57 (21) | 12/58 (21) | 6/23 (26) | |||||
Patient mast cells indicates the frequency of patients carrying KIT mutation in their mast cells, from all patients analyzed. All other data shows patients with KIT mutation-positive mast cells. Results expressed as number of cases with the KIT mutation from all cases analyzed (N). All but 3 patients had the D816V KIT mutation.
NA indicates not analyzed.
One patient had the D816Y KIT mutation.
One patient had the VI815-816 insertion in the KIT sequence.
One patient had the I817V KIT mutation.
P < .001 compared with the WDSM group.
P < .05 compared with the WDSM group.
P < .01 compared with the WDSM group.