Table 3.

Involvement of different hematopoietic cell lineages in patients with SM-AHNMD as evaluated by the presence or absence of somatic activating KIT mutations at codon 816

ISM
ASM
AMLB-CLLMDSPVLPLMDS
CMML
Cell type
Patient 1
Patient 2
Patient 3
Patient 4
Patient 5
Patient 6
Patient 7
Patient 8
Patient 9
Mast cells, %   0.7 +   0.03 +   0.9 +   0.1 +   0.3 +   7.5 +   6 +   0.22 +   0.2 +  
CD34+ HPCs, %   7.7 +*  1.6 +   10 -   1.9 +   0.5 -   0.8 +   2 +   NA   1 +  
Eosinophils, %   1.1 +   1.1 +   1.7 -   1.4 -   5.8 -   4.8 +   8.7 +   7.4 +   3.2 +  
Monocytes, %   3.7 +   NA   4.2 -   3.2 -   9.2 -   2.9 +   12 +   31 +   11 +  
Neutrophil lineage cells, %   73 +*  NA   49 -   52 -   54 -   66 +   NA   46 +   67 +  
Erythroid precursors, %   12 +   NA   NA   NA   7.8 -   NA   NA   NA   NA  
Lymphocytes, %
 		 2.2 +
 		 19 -†
 		 NA
 		 NA
 		 6.1 -†
 		 NA
 		 NA
 		 11.4 +
 		 NA
 
ISM
ASM
AMLB-CLLMDSPVLPLMDS
CMML
Cell type
Patient 1
Patient 2
Patient 3
Patient 4
Patient 5
Patient 6
Patient 7
Patient 8
Patient 9
Mast cells, %   0.7 +   0.03 +   0.9 +   0.1 +   0.3 +   7.5 +   6 +   0.22 +   0.2 +  
CD34+ HPCs, %   7.7 +*  1.6 +   10 -   1.9 +   0.5 -   0.8 +   2 +   NA   1 +  
Eosinophils, %   1.1 +   1.1 +   1.7 -   1.4 -   5.8 -   4.8 +   8.7 +   7.4 +   3.2 +  
Monocytes, %   3.7 +   NA   4.2 -   3.2 -   9.2 -   2.9 +   12 +   31 +   11 +  
Neutrophil lineage cells, %   73 +*  NA   49 -   52 -   54 -   66 +   NA   46 +   67 +  
Erythroid precursors, %   12 +   NA   NA   NA   7.8 -   NA   NA   NA   NA  
Lymphocytes, %
 		 2.2 +
 		 19 -†
 		 NA
 		 NA
 		 6.1 -†
 		 NA
 		 NA
 		 11.4 +
 		 NA
 

Results expressed as percentage of cells from all nucleated BM cells.

NA indicates not analyzed; +, presence of KIT mutation; and -, absence of KIT mutation.

*

Including blast cells.

†

Including neoplastic B-cells.

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