Hematologic parameters in 14-week-old +/+ and fch/fch mice in the three congenic strains
| Genotype . | Ht, proportion of 1 . | Hb level, g/L . | RBC count, × 1012/L . | MCV, fL . | RET, % RBC . | MCHC, g/dL . |
|---|---|---|---|---|---|---|
| BALB/c | ||||||
| +/+ | 0.481 ± 0.001 | 164 ± 3 | 10.2 ± 0.2 | 51.1 ± 2.1 | 2.5 ± 0.6 | 33.6 ± 0.4 |
| fch/fch | 0.356 ± 0.017* | 104 ± 6* | 7.7 ± 0.5* | 43.9 ± 1.0* | 8.8 ± 3.4† | 28.7 ± 1.2† |
| SJL/L | ||||||
| +/+ | 0.434 ± 0.016 | 140 ± 9 | 9.3 ± 0.4 | 46.8 ± 1.0 | 3.9 ± 1.8 | 31.9 ± 0.8 |
| fch/fch | 0.338 ± 0.017* | 126 ± 4‡ | 7.1 ± 0.3* | 44.1 ± 1.0† | 6.5 ± 1.1‡ | 29.9 ± 0.5‡ |
| C57BL/6 | ||||||
| +/+ | 0.405 ± 0.035 | 127 ± 1 | 8.6 ± 0.5 | 47.8 ± 1.4 | 4.8 ± 2.6 | 31.4 ± 0.5 |
| fch/fch | 0.325 ± 0.025† | 114 ± 2‡ | 7.3 ± 0.3† | 42.6 ± 1.9* | 6.5 ± 1.0‡ | 30.3 ± 1.‡ |
| Genotype . | Ht, proportion of 1 . | Hb level, g/L . | RBC count, × 1012/L . | MCV, fL . | RET, % RBC . | MCHC, g/dL . |
|---|---|---|---|---|---|---|
| BALB/c | ||||||
| +/+ | 0.481 ± 0.001 | 164 ± 3 | 10.2 ± 0.2 | 51.1 ± 2.1 | 2.5 ± 0.6 | 33.6 ± 0.4 |
| fch/fch | 0.356 ± 0.017* | 104 ± 6* | 7.7 ± 0.5* | 43.9 ± 1.0* | 8.8 ± 3.4† | 28.7 ± 1.2† |
| SJL/L | ||||||
| +/+ | 0.434 ± 0.016 | 140 ± 9 | 9.3 ± 0.4 | 46.8 ± 1.0 | 3.9 ± 1.8 | 31.9 ± 0.8 |
| fch/fch | 0.338 ± 0.017* | 126 ± 4‡ | 7.1 ± 0.3* | 44.1 ± 1.0† | 6.5 ± 1.1‡ | 29.9 ± 0.5‡ |
| C57BL/6 | ||||||
| +/+ | 0.405 ± 0.035 | 127 ± 1 | 8.6 ± 0.5 | 47.8 ± 1.4 | 4.8 ± 2.6 | 31.4 ± 0.5 |
| fch/fch | 0.325 ± 0.025† | 114 ± 2‡ | 7.3 ± 0.3† | 42.6 ± 1.9* | 6.5 ± 1.0‡ | 30.3 ± 1.‡ |
Data represent mean ± SD of 6 mice per group. RBC, Hb, Ht, MCV, RET, and MCHC in female FECH-deficient mice (fch/fch) and wild-type (+/+) mice.
*P < .001.
†P < .01.
‡Not significant.