Iron parameters in 14-week-old +/+ and fch/fch BALB/c mice
| Biological parameter . | BALB/c +/+ . | BALB/c fch/fch . |
|---|---|---|
| Serum | ||
| Transferrin, g/L | 1.4 ± 0.1 | 2.8 ± 0.1* |
| Transferrin saturation, % | 87 ± 8 | 44 ± 3* |
| Ferritin, μg/L | 46 ± 13.2 | 66 ± 19.5† |
| Iron, μM | 29.7 ± 3.5 | 31.8 ± 2.7† |
| Haptoglobin, g/L | 0.3 ± 0.05 | 0.26 ± 0.1† |
| Liver | ||
| Hepcidin/Gapdh mRNA | 0.8 ± 0.5 | 1.2 ± 0.1† |
| Duodenum | ||
| Dcytb/Gapdh mRNA | 1.2 ± 0.2 | 1.1 ± 0.4† |
| Ferrireductase activity, μmoles · e− transferred × min−1 × μg protein−1 | 0.25 ± 0.03 | 0.21 ± 0.05† |
| Biological parameter . | BALB/c +/+ . | BALB/c fch/fch . |
|---|---|---|
| Serum | ||
| Transferrin, g/L | 1.4 ± 0.1 | 2.8 ± 0.1* |
| Transferrin saturation, % | 87 ± 8 | 44 ± 3* |
| Ferritin, μg/L | 46 ± 13.2 | 66 ± 19.5† |
| Iron, μM | 29.7 ± 3.5 | 31.8 ± 2.7† |
| Haptoglobin, g/L | 0.3 ± 0.05 | 0.26 ± 0.1† |
| Liver | ||
| Hepcidin/Gapdh mRNA | 0.8 ± 0.5 | 1.2 ± 0.1† |
| Duodenum | ||
| Dcytb/Gapdh mRNA | 1.2 ± 0.2 | 1.1 ± 0.4† |
| Ferrireductase activity, μmoles · e− transferred × min−1 × μg protein−1 | 0.25 ± 0.03 | 0.21 ± 0.05† |
Data represent mean ± SD of 10 mice per group in FECH-deficient (fch/fch) and wild-type (+/+) BALB/c female mice.
*P < .001.
†Not significant.