Patient characteristics by site
| Characteristic . | Site 1 . | Site 2 . | P* . |
|---|---|---|---|
| No. | 41 | 23 | |
| Rai stage | |||
| Low | 2 | 1 | |
| Intermediate | 13 | 14 | .049 |
| High | 26 | 8 | |
| 0 | 2 | 1 | |
| 1 | 4 | 7 | |
| 2 | 9 | 7 | .019 |
| 3 | 12 | 5 | |
| 4 | 14 | 3 | |
| Sex | |||
| Male | 32 | 17 | .76 |
| Female | 9 | 6 | |
| Age, y | |||
| Younger than 70 | 29 | 17 | |
| 70 and older | 12 | 6 | .99 |
| ECOG PS | |||
| 0 | 29 | 5 | |
| 1 | 11 | 13 | .001 |
| 2 | 1 | 4 | |
| 3 | 0 | 1 | |
| CD38+ B cells | |||
| 30% or less | 26 | 15 | .99 |
| Greater than 30% | 13 | 8 | |
| ZAP-70 B cells | |||
| 20% or less | 20 | 15 | .07 |
| Greater than 20% | 15 | 3 | |
| VH status | |||
| Mutated | 12 | 6 | .99 |
| Nonmutated | 29 | 15 | |
| FISH | |||
| Normal | 6 | 1 | |
| +12 | 8 | 3 | |
| 11q- | 9 | 4 | |
| 17p- | 0 | 3 | |
| 6q- | 1 | 0 | |
| 13q- | 10 | 10 | |
| 13q - x1 | 7 | 8 | |
| 13q - x2 | 3 | 2 | |
| Other | 2 | 1 | |
| No. of genetic defects | |||
| 0 | 6 | 1 | |
| 1 | 16 | 14 | .90 |
| 2+ | 14 | 7 | |
| Bone marrow pattern | |||
| Diffuse | 12 | 19 | < .001 |
| Not diffuse | 29 | 2 | |
| Characteristic . | Site 1 . | Site 2 . | P* . |
|---|---|---|---|
| No. | 41 | 23 | |
| Rai stage | |||
| Low | 2 | 1 | |
| Intermediate | 13 | 14 | .049 |
| High | 26 | 8 | |
| 0 | 2 | 1 | |
| 1 | 4 | 7 | |
| 2 | 9 | 7 | .019 |
| 3 | 12 | 5 | |
| 4 | 14 | 3 | |
| Sex | |||
| Male | 32 | 17 | .76 |
| Female | 9 | 6 | |
| Age, y | |||
| Younger than 70 | 29 | 17 | |
| 70 and older | 12 | 6 | .99 |
| ECOG PS | |||
| 0 | 29 | 5 | |
| 1 | 11 | 13 | .001 |
| 2 | 1 | 4 | |
| 3 | 0 | 1 | |
| CD38+ B cells | |||
| 30% or less | 26 | 15 | .99 |
| Greater than 30% | 13 | 8 | |
| ZAP-70 B cells | |||
| 20% or less | 20 | 15 | .07 |
| Greater than 20% | 15 | 3 | |
| VH status | |||
| Mutated | 12 | 6 | .99 |
| Nonmutated | 29 | 15 | |
| FISH | |||
| Normal | 6 | 1 | |
| +12 | 8 | 3 | |
| 11q- | 9 | 4 | |
| 17p- | 0 | 3 | |
| 6q- | 1 | 0 | |
| 13q- | 10 | 10 | |
| 13q - x1 | 7 | 8 | |
| 13q - x2 | 3 | 2 | |
| Other | 2 | 1 | |
| No. of genetic defects | |||
| 0 | 6 | 1 | |
| 1 | 16 | 14 | .90 |
| 2+ | 14 | 7 | |
| Bone marrow pattern | |||
| Diffuse | 12 | 19 | < .001 |
| Not diffuse | 29 | 2 | |
P values represent where significant differences were seen between the 2 participating sites.