Univariate and multivariate analyses with prognostic factors for relapse-free survival
| Variable . | No. . | Relapse, no. (%) . | 5-y RFS, ± 95% CI . | Univariate analysis . | Multivariate analysis . | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | ||||
| Sex | |||||||||
| Female | 84 | 9 (10.7) | 87.4 ± 7.7 | — | — | — | — | ||
| Male | 138 | 28 (20.3) | 73.9 ± 9.3 | 1.864 | 0.879-3.950 | .104 | 1.367 | 0.599-3.120 | .458 |
| Age | |||||||||
| 1 y to less than 10 y | 161 | 20 (12.4) | 83.4 ± 7.3 | — | — | — | — | ||
| At least 10 y or younger than 1 y | 61 | 17 (27.8) | 65.3 ± 14.2 | 3.425 | 1.778-6.598 | < .001 | 2.095 | 0.996-4.406 | .051 |
| Leukocyte count | |||||||||
| Less than 50 × 109/L | 166 | 20 (12.0) | 83.6 ± 8.9 | — | — | — | — | ||
| At least 50 × 109/L | 56 | 17 (30.4) | 61.7 ± 15.2 | 3.457 | 1.806-6.617 | < .001 | 1.537 | 0.617-3.827 | .356 |
| Immunophenotype | |||||||||
| Precursor B cell | 171 | 24 (14.0) | 80.8 ± 7.6 | — | — | — | — | ||
| Others | 49 | 13 (26.5) | 70.5 ± 14.2 | 2.139 | 1.088-4.204 | .027 | 1.186 | 0.491-2.868 | .705 |
| No. of chromosomes | .805 | .425 | |||||||
| At least 50 | 26 | 5 (19.2) | 65.4 ± 29.0 | — | — | — | — | ||
| 45-49 | 168 | 27 (16.1) | 81.6 ± 6.6 | 0.730 | 0.280-1.899 | .518 | 0.499 | 0.171-1.455 | .203 |
| 44 or fewer | 9 | 2 (22.2) | 75.0 ± 30.0 | 0.839 | 0.162-4.352 | .834 | 0.689 | 0.118-4.038 | .680 |
| Structural abnormality of chromosome | < .001 | .033 | |||||||
| t(12;21) | 35 | 2 (5.7) | 93.6 ± 8.6 | — | — | — | — | ||
| Absent or others | 155 | 19 (12.3) | 83.1 ± 7.7 | 2.342 | 0.545-10.054 | .252 | 0.630 | 0.131-3.036 | .565 |
| t(9;22) or 11g23 rearrangement | 32 | 16 (50.0) | 39.7 ± 23.0 | 12.742 | 2.923-55.550 | .001 | 1.923 | 0.344-10.754 | .457 |
| Livin expression | |||||||||
| Expressed | 57 | 1 (1.8) | 97.9 ± 4.0 | — | — | — | — | ||
| Not expressed | 165 | 36 (21.8) | 71.4 ± 9.0 | 15.098 | 2.069-110.195 | .007 | 8.844 | 1.010-77.479 | .049 |
| Variable . | No. . | Relapse, no. (%) . | 5-y RFS, ± 95% CI . | Univariate analysis . | Multivariate analysis . | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | ||||
| Sex | |||||||||
| Female | 84 | 9 (10.7) | 87.4 ± 7.7 | — | — | — | — | ||
| Male | 138 | 28 (20.3) | 73.9 ± 9.3 | 1.864 | 0.879-3.950 | .104 | 1.367 | 0.599-3.120 | .458 |
| Age | |||||||||
| 1 y to less than 10 y | 161 | 20 (12.4) | 83.4 ± 7.3 | — | — | — | — | ||
| At least 10 y or younger than 1 y | 61 | 17 (27.8) | 65.3 ± 14.2 | 3.425 | 1.778-6.598 | < .001 | 2.095 | 0.996-4.406 | .051 |
| Leukocyte count | |||||||||
| Less than 50 × 109/L | 166 | 20 (12.0) | 83.6 ± 8.9 | — | — | — | — | ||
| At least 50 × 109/L | 56 | 17 (30.4) | 61.7 ± 15.2 | 3.457 | 1.806-6.617 | < .001 | 1.537 | 0.617-3.827 | .356 |
| Immunophenotype | |||||||||
| Precursor B cell | 171 | 24 (14.0) | 80.8 ± 7.6 | — | — | — | — | ||
| Others | 49 | 13 (26.5) | 70.5 ± 14.2 | 2.139 | 1.088-4.204 | .027 | 1.186 | 0.491-2.868 | .705 |
| No. of chromosomes | .805 | .425 | |||||||
| At least 50 | 26 | 5 (19.2) | 65.4 ± 29.0 | — | — | — | — | ||
| 45-49 | 168 | 27 (16.1) | 81.6 ± 6.6 | 0.730 | 0.280-1.899 | .518 | 0.499 | 0.171-1.455 | .203 |
| 44 or fewer | 9 | 2 (22.2) | 75.0 ± 30.0 | 0.839 | 0.162-4.352 | .834 | 0.689 | 0.118-4.038 | .680 |
| Structural abnormality of chromosome | < .001 | .033 | |||||||
| t(12;21) | 35 | 2 (5.7) | 93.6 ± 8.6 | — | — | — | — | ||
| Absent or others | 155 | 19 (12.3) | 83.1 ± 7.7 | 2.342 | 0.545-10.054 | .252 | 0.630 | 0.131-3.036 | .565 |
| t(9;22) or 11g23 rearrangement | 32 | 16 (50.0) | 39.7 ± 23.0 | 12.742 | 2.923-55.550 | .001 | 1.923 | 0.344-10.754 | .457 |
| Livin expression | |||||||||
| Expressed | 57 | 1 (1.8) | 97.9 ± 4.0 | — | — | — | — | ||
| Not expressed | 165 | 36 (21.8) | 71.4 ± 9.0 | 15.098 | 2.069-110.195 | .007 | 8.844 | 1.010-77.479 | .049 |
Prognostic effect of each variable was estimated using Cox regression analysis. Statistical significance was accepted when P values were less than .05.
HR indicates hazard ratio; CI, confidence interval; —, not applicable (reference category).