Table 2.

Common regions of genomic copy number gain and loss in 64 DLBCL specimens

Chr, region, and subregion, Mbp
No. clones
Size, Mbp
Max freq, %
Gain     
1    
143.2-256.2   94   113.0   35.9  
149.5-157.3   6   7.8   35.9  
184.6-204.3   18   19.7   29.0  
2    
1.9-70.4   53   68.5   21.9  
9.0-56.0   30   47.0   20.3  
59.3-63.9   5   4.6   21.9  
3    
0.2-204.6   162   204.4   26.0  
10.9-11.0   2   0.1   24.5  
137.4-188.7   48   51.3   26.0  
5    
0-100.6   58   100.6   26.6  
0-0.5   2   0.5   26.6  
107.0-112.5   4   5.5   11.7  
131.4-146.3   13   14.9   14.1  
150.4-158.1   7   7.7   13.5  
171.2-180.7   4   9.5   12.5  
6    
0.1-57.1   64   57.0   26.6  
0.1-5.9   10   5.8   26.6  
7    
0-158.2   134   158.2   32.8  
0-0.1   2   0.1   32.3  
71.5-73.7   8   2.2   32.0  
136.7-158.2   12   21.5   32.8  
9    
0-66.6   45   66.4   16.4  
0-64.9   43   64.7   16.4  
83.9-95.3   15   11.4   12.5  
117.6-134.3   22   16.7   19.5  
122.1-132.8   12   10.7   19.5  
10    
102.1-102.9   2   0.8   14.1  
105.5-105.7   2   0.2   12.0  
11    
0.8-36.6   32   35.8   14.1  
57.7-134.6   79   76.9   25.8  
61.5-76.8   16   15.3   24.2  
112.0-123.3   14   11.3   25.8  
12    
0-133.3   126   133.3   46.1  
0-0.1   2   0.1   46.1  
45.4-53.8   9   8.4   38.4  
13    
18.7-52.4   36   33.7   15.6  
70.5-114.0   50   43.5   21.4  
85.0-91.9   11   6.9   21.1  
110.1-114.0   9   3.9   21.4  
16    
0.1-31.3   29   31.2   18.8  
0.1-4.7   8   4.6   18.8  
62.4-89.7   19   27.3   17.2  
67.5-89.7   16   22.2   17.2  
17    
0.1-84.0   75   83.9   26.0  
39.5-50.1   8   10.6   26.0  
18    
4.5-77.6   42   73.1   16.4  
10.0-77.6   39   67.6   16.4  
19    
0.2-63.7   36   63.5   18.8  
43.1-63.7   17   20.6   18.8  
20    
0.3-4.7   9   4.4   13.3  
22.5-63.6   44   41.1   19.5  
52.0-63.6   14   11.6   19.5  
21    
15.1-46.9   26   31.8   17.2  
29.4-46.9   13   17.5   17.2  
22    
16.6-49.3   33   32.7   17.3  
Loss    
1    
1.0-82.8   90   81.8   25.7  
1.5-9.0   10   7.5   24.2  
78.2-79.1   2   0.9   25.7  
2    
2.4-4.1   2   1.7   11.7  
104.2-159.9   54   55.7   15.9  
241.0-241.7   2   0.7   15.6  
4    
0-0.7   2   0.7   10.9  
16.1-190.6   140   174.5   27.3  
24.9-34.7   7   9.8   19.5  
178.3-190.6   14   12.3   27.3  
6    
62.2-170.5   118   108.3   40.8  
128.7-155.7   28   27.0   40.8  
7    
11.7-17.3   8   5.6   12.5  
18.8-19.2   8   0.4   17.2  
18.8-19.2   6   0.4   17.2  
8    
0.4-4.0   7   3.6   12.6  
14.9-22.6   8   7.7   11.9  
9    
8.3-12.5   4   4.2   15.6  
10    
47.0-62.8   16   15.8   19.5  
54.6-58.5   6   3.9   19.5  
107.0-120.0   14   13.0   14.1  
131.5-135.2   10   3.7   14.1  
11    
26.7-31.4   5   4.7   10.9  
126.4-134.6   12   8.2   21.2  
130.6-134.6   8   4.0   21.2  
13    
35.9-72.8   29   36.9   22.7  
59.4-66.5   6   7.1   22.7  
105.7-106.2   2   0.5   10.9  
14    
86.7-105.1   18   18.4   17.2  
90.1-105.1   15   15.0   17.2  
15    
20.4-99.7   78   79.3   24.2  
41.2-45.5   7   4.3   24.2  
80.7-99.7   20   19.0   18.8  
16    
33.8-35.6   2   1.8   11.2  
61.2-62.4   2   1.2   11.7  
17    
0.1-19.8   29   19.7   16.4  
0.1-15.4   27   15.3   16.4  
18    
66.2-66.6   4   0.4   12.5  
21    
19.3-27.8
 		 10
 		 8.5
 		 13.3
 
Chr, region, and subregion, Mbp
No. clones
Size, Mbp
Max freq, %
Gain     
1    
143.2-256.2   94   113.0   35.9  
149.5-157.3   6   7.8   35.9  
184.6-204.3   18   19.7   29.0  
2    
1.9-70.4   53   68.5   21.9  
9.0-56.0   30   47.0   20.3  
59.3-63.9   5   4.6   21.9  
3    
0.2-204.6   162   204.4   26.0  
10.9-11.0   2   0.1   24.5  
137.4-188.7   48   51.3   26.0  
5    
0-100.6   58   100.6   26.6  
0-0.5   2   0.5   26.6  
107.0-112.5   4   5.5   11.7  
131.4-146.3   13   14.9   14.1  
150.4-158.1   7   7.7   13.5  
171.2-180.7   4   9.5   12.5  
6    
0.1-57.1   64   57.0   26.6  
0.1-5.9   10   5.8   26.6  
7    
0-158.2   134   158.2   32.8  
0-0.1   2   0.1   32.3  
71.5-73.7   8   2.2   32.0  
136.7-158.2   12   21.5   32.8  
9    
0-66.6   45   66.4   16.4  
0-64.9   43   64.7   16.4  
83.9-95.3   15   11.4   12.5  
117.6-134.3   22   16.7   19.5  
122.1-132.8   12   10.7   19.5  
10    
102.1-102.9   2   0.8   14.1  
105.5-105.7   2   0.2   12.0  
11    
0.8-36.6   32   35.8   14.1  
57.7-134.6   79   76.9   25.8  
61.5-76.8   16   15.3   24.2  
112.0-123.3   14   11.3   25.8  
12    
0-133.3   126   133.3   46.1  
0-0.1   2   0.1   46.1  
45.4-53.8   9   8.4   38.4  
13    
18.7-52.4   36   33.7   15.6  
70.5-114.0   50   43.5   21.4  
85.0-91.9   11   6.9   21.1  
110.1-114.0   9   3.9   21.4  
16    
0.1-31.3   29   31.2   18.8  
0.1-4.7   8   4.6   18.8  
62.4-89.7   19   27.3   17.2  
67.5-89.7   16   22.2   17.2  
17    
0.1-84.0   75   83.9   26.0  
39.5-50.1   8   10.6   26.0  
18    
4.5-77.6   42   73.1   16.4  
10.0-77.6   39   67.6   16.4  
19    
0.2-63.7   36   63.5   18.8  
43.1-63.7   17   20.6   18.8  
20    
0.3-4.7   9   4.4   13.3  
22.5-63.6   44   41.1   19.5  
52.0-63.6   14   11.6   19.5  
21    
15.1-46.9   26   31.8   17.2  
29.4-46.9   13   17.5   17.2  
22    
16.6-49.3   33   32.7   17.3  
Loss    
1    
1.0-82.8   90   81.8   25.7  
1.5-9.0   10   7.5   24.2  
78.2-79.1   2   0.9   25.7  
2    
2.4-4.1   2   1.7   11.7  
104.2-159.9   54   55.7   15.9  
241.0-241.7   2   0.7   15.6  
4    
0-0.7   2   0.7   10.9  
16.1-190.6   140   174.5   27.3  
24.9-34.7   7   9.8   19.5  
178.3-190.6   14   12.3   27.3  
6    
62.2-170.5   118   108.3   40.8  
128.7-155.7   28   27.0   40.8  
7    
11.7-17.3   8   5.6   12.5  
18.8-19.2   8   0.4   17.2  
18.8-19.2   6   0.4   17.2  
8    
0.4-4.0   7   3.6   12.6  
14.9-22.6   8   7.7   11.9  
9    
8.3-12.5   4   4.2   15.6  
10    
47.0-62.8   16   15.8   19.5  
54.6-58.5   6   3.9   19.5  
107.0-120.0   14   13.0   14.1  
131.5-135.2   10   3.7   14.1  
11    
26.7-31.4   5   4.7   10.9  
126.4-134.6   12   8.2   21.2  
130.6-134.6   8   4.0   21.2  
13    
35.9-72.8   29   36.9   22.7  
59.4-66.5   6   7.1   22.7  
105.7-106.2   2   0.5   10.9  
14    
86.7-105.1   18   18.4   17.2  
90.1-105.1   15   15.0   17.2  
15    
20.4-99.7   78   79.3   24.2  
41.2-45.5   7   4.3   24.2  
80.7-99.7   20   19.0   18.8  
16    
33.8-35.6   2   1.8   11.2  
61.2-62.4   2   1.2   11.7  
17    
0.1-19.8   29   19.7   16.4  
0.1-15.4   27   15.3   16.4  
18    
66.2-66.6   4   0.4   12.5  
21    
19.3-27.8
 		 10
 		 8.5
 		 13.3
 

Chr indicates chromosome; Max freq, maximum frequency.

Maximum frequency is the average of the frequencies of the 2 most frequent adjacent clones within a region or subregion.

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