Notch1 mutations in murine primary pre-T LBL tumors
Strain and mouse . | Mutation . |
|---|---|
| SCL/LMO1 | |
| 2383 | 66494GC>G (PEST) |
| 2853 | 66391CGG>CCCG (PEST) |
| 3781 | 66279C>CT (PEST) |
| 3911 | 66280G>TC (PEST) |
| 3917 | None |
| 6180/1 | 66571CCCC>CCCCC (PEST) |
| 6385/4 | None |
| 6472/3 | Del 66449-61 (PEST) |
| 6600/1 | 66391C>CAAAA (PEST) |
| 6603/5 | None |
| 6605/4 | 66391C>CAG (PEST)/Dup of 66408-67 (60 bp) (PEST) |
| 6645/4 | 66391C>CATATAGGG (PEST) |
| 6775/1 | 66383TGTGA>GGGAGGAGGGGTG (PEST) |
| 6781/2 | None |
| 6781/3 | 59724T>C (L→P) (HD) |
| 6782/2 | 66280G>CC (PEST) |
| 6812/1 | 66279C>CAAAA (PEST) |
| 6812/2 | 66280G>AAAAA (PEST) |
| 6846/2 | 66567CTG>CTGTG (PEST) hom |
| 6858/4 | 66533C>CATCC (PEST) |
| 6860/1 | None |
| 6990/3 | Del 66451-61 (PEST) |
| 7114/1 | 66392GGCAG>CCC (PEST) |
| 7114/3 | 66392G>TGCCCCCCT (PEST) |
| 7277/3 | None |
| 7298/2 | 66279C>GCCCC (PEST) |
| OLIG2 | |
| 556 | None |
| 1115 | None |
| OLIG2/LMO1* | |
| 259 | 58374T>C (W→R) (HD) |
| 262 | 58462T>A (L→Q) (HD) |
| 1919 | None |
| 1928 | None |
| 1931 | None |
| 1939 | 66508AGG>AGGG (PEST) |
| LMO1 | |
| 255 | None |
| 12/1 | 66408C>CCCAGCCAATGGGCACC (PEST) |
| NUP98/HOXD13 | |
| L7 | None |
| 1018 | 66452A>AGTCCGGGCCCC (PEST) |
| 1075 | None |
| 1901 | None |
| 2423 | None |
| 2553 | None |
| 2738 | 66328G>GT (PEST) |
| 2918 | None |
| 8013 | 58429T>C (L→P) (HD) |
| p27−/−, SMAD3−/+ | |
| 137 | None |
| 198 | None† |
| 27-1 | None†, 59790C>G (A→G) (HD) |
| 32-6 | 59844T>G (I→S) (HD) |
Strain and mouse . | Mutation . |
|---|---|
| SCL/LMO1 | |
| 2383 | 66494GC>G (PEST) |
| 2853 | 66391CGG>CCCG (PEST) |
| 3781 | 66279C>CT (PEST) |
| 3911 | 66280G>TC (PEST) |
| 3917 | None |
| 6180/1 | 66571CCCC>CCCCC (PEST) |
| 6385/4 | None |
| 6472/3 | Del 66449-61 (PEST) |
| 6600/1 | 66391C>CAAAA (PEST) |
| 6603/5 | None |
| 6605/4 | 66391C>CAG (PEST)/Dup of 66408-67 (60 bp) (PEST) |
| 6645/4 | 66391C>CATATAGGG (PEST) |
| 6775/1 | 66383TGTGA>GGGAGGAGGGGTG (PEST) |
| 6781/2 | None |
| 6781/3 | 59724T>C (L→P) (HD) |
| 6782/2 | 66280G>CC (PEST) |
| 6812/1 | 66279C>CAAAA (PEST) |
| 6812/2 | 66280G>AAAAA (PEST) |
| 6846/2 | 66567CTG>CTGTG (PEST) hom |
| 6858/4 | 66533C>CATCC (PEST) |
| 6860/1 | None |
| 6990/3 | Del 66451-61 (PEST) |
| 7114/1 | 66392GGCAG>CCC (PEST) |
| 7114/3 | 66392G>TGCCCCCCT (PEST) |
| 7277/3 | None |
| 7298/2 | 66279C>GCCCC (PEST) |
| OLIG2 | |
| 556 | None |
| 1115 | None |
| OLIG2/LMO1* | |
| 259 | 58374T>C (W→R) (HD) |
| 262 | 58462T>A (L→Q) (HD) |
| 1919 | None |
| 1928 | None |
| 1931 | None |
| 1939 | 66508AGG>AGGG (PEST) |
| LMO1 | |
| 255 | None |
| 12/1 | 66408C>CCCAGCCAATGGGCACC (PEST) |
| NUP98/HOXD13 | |
| L7 | None |
| 1018 | 66452A>AGTCCGGGCCCC (PEST) |
| 1075 | None |
| 1901 | None |
| 2423 | None |
| 2553 | None |
| 2738 | 66328G>GT (PEST) |
| 2918 | None |
| 8013 | 58429T>C (L→P) (HD) |
| p27−/−, SMAD3−/+ | |
| 137 | None |
| 198 | None† |
| 27-1 | None†, 59790C>G (A→G) (HD) |
| 32-6 | 59844T>G (I→S) (HD) |
Mutations were heterozygous unless otherwise noted. For SCL/LMO1, n = 26; for OLIG2, n = 2; for OLIG2/LMO1, n = 6; for LMO1, n = 2; for NUP98/HOXD13, n = 9; and for p27−/−, SMAD3−/+, n = 4.
Del indicates deletion; Dup, duplication; hom, homozygous; none, no mutation.
Previously reported (Lin et al8 ).
Polymorphism at 58623G>A in the HD.